phosphodiester bond

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phos·pho·di·es·ter bond

A covalent chemical bond that links two carbon atoms through a phosphate group, especially the bonds that link the pentose sugars of adjacent nucleotides in polynucleotide chains of RNA and DNA.

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ROS cleave the phosphodiester bonds holding bases in RNA and DNA together, breaking the chain structure of RNA and DNA.
CdtB exhibits DNase I activity, disrupting the phosphodiester bonds in chromosomal DNA.
The phosphodiester bonds of ATP contain the energy necessary to drive reactions in living systems, giving up their stored energy when these bonds are chemically cleaved.
Cutting DNA: Endonucleases destroy internal phosphodiester bonds in the DNA molecule.

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