The Targeting Antibiotic Non-susceptible Gram-negative Organisms, or TANGO 1, trial was the pivotal Phase 3 study that compared the efficacy and safety of Vabomere to piperacillin-tazobactam
in the treatment of patients with cUTI and acute pyelonephritis.
5 [micro]g/mL), was 8-fold more potent than piperacillin-tazobactam
The FDA approval of Vabomere was supported by TANGO-1, a Phase III, multi-center, randomized, double-blind, double-dummy study to evaluate the efficacy, safety and tolerability of Vabomere compared to piperacillin-tazobactam
in the treatment of cUTI, including acute pyelonephritis, in adults.
None of the isolates showed resistance to cefoperazone-sulbactam, imipenem, piperacillin-tazobactam
Argentinean collaborative multicenter study on the in vitro comparative activity of piperacillin-tazobactam
against selected bacterial isolates recovered from hospitalized patients.
For Gram-negative bacilli ampicillin, cefixime, ceftriaxone, cotrimoxazole, ciprofloxacin, ofloxacin, gentamicin, amikacin, amoxicillin-clavulanic acid, cefoperazone-sulbactam, piperacillin-tazobactam
, and Imipenem were used.
Contract notice: Supply antibiotics (linezolid, piperacillin-tazobactam
putida sensitive to cefepime, gentamycin, ciprofloxacin, and amikacin, but resistant to meropenem and piperacillin-tazobactam
Carbavance demonstrated statistical superiority over piperacillin-tazobactam
with overall success in 98.
The top 10 antimicrobials they reported as being in short supply were piperacillin-tazobactam
, ampicillin-sulbactam, meropenem, cefotaxime, cefepime, trimethoprim-sulfamethoxazole (TMP-SMX), doxycycline, imipenem, acyclovir, and amikacin.
One log2 dilution of the breakpoints was 62% for ceftazidime, and 59% for piperacillin-tazobactam
(Sader et al.
046) of the isolates were sensitive to piperacillin-tazobactam