Animals kingdom produce antibodies against pathogen or vaccine, similarly plants response to pathogen attack by producing PR-proteins, defense-related enzymes (Thangavelu et al., 2007), plantibodies
: A very recent approach for vaccination strategies is molecular biological techniques to express bacterial or viral antigens in plants, which could be used as orally administered vaccines.
The concept of using plants for recombinant antibodies (plantibodies
) production (Figure 1) was first reported in 1983.
The company uses its LEX System and "Plantibodies
" technologies for harvesting proteins from Lemna, an aquatic plant, and genetically transforming them into monoclonal antibodies for use in treating human diseases such as hepatitis C.
To create the "plantibodies
," Baillie and his colleagues first collected cells that make antibodies from individuals who had been vaccinated against anthrax.
This is the first patent ever awarded for the use of "plantibodies
" (plant-made antibodies) to treat humans.
That had raised concerns that these "plantibodies
" wouldn't work as effectively as normal ones or that a mammalian immune system would perceive them as foreign.