The increase was primarily due to a $2.6 million increase from Plaquenil
authorized generic due to the timing of shipments in 2019; a $1.0 million increase from recently acquired Salagen and Panretin brands in the U.S.
In the retrospective, nonrandomized study, 15 women and 6 men with erosive, recalcitrant oral lichen planus were treated with hydroxychloroquine (Plaquenil
) at a dose of 200 mg/day, which was increased to 400 mg/day at 1 month.
, or quinine are the drugs of choice; but it does respond well to natural medications and often requires multiple supports and medications.
A total of 50% of the participants were taking 10 mg or more of prednisone, 80% were taking daily Plaquenil
, and 80% had taken immunosuppressants (38% Benlysta, 67% CellCept, and 11% Rituxan).
Traditional DMARDs include methotrexate, hydroxychloroquine (Plaquenil
), and sulfasalazine (Azulfidine).
Four other Medicaid drugs increased more than 300% year over year: Epitol, an anticonvulsant (460%); the antimalaria drug Hydroxychloroquine Sulfate, or Plaquenil
, (489%); Phenergan (417%), an allergy medication; and Daraprim (874%), from Turing Pharmaceuticals AG.
The most common, and oldest, DMARD is methotrexate, which is deemed effective, safe and inexpensive, though it carries some side effects, as do the other DMARDs, such as hydroxychloroquine (Plaquenil
), sulfasalazine (Azulfidine), and leflunomide (Arava).
Troum of the University of Southern California in Los Angeles highlighted key developments in osteoarthritis during the past year, including two major studies on total knee replacement, the Food and Drug Administration's updated stronger warning on the cardiac and stroke risks of NSAIDs, a randomized trial that effectively takes hydroxychloroquine (Plaquenil
) off the treatment menu for hand osteoarthritis, and a reassuring report on the safety of repeated intra-articular corticosteroid injections in patients with synovitic knee osteoarthritis.
The patient tried to use the topical solution clobetasol, scalp injections, and plaquenil
Key products are Nilandron, for the treatment of metastatic prostate cancer; Dibenzyline, for the treatment of pheochromocytoma; Lanoxin, for the treatment of mild-to-moderate heart failure and atrial fibrillation; and, Plaquenil
, for the treatment of lupus and rheumatoid arthritis.
"I remember when I was a fellow a paper was published saying Plaquenil
[hydroxychloroquine] is safer than aspirin, it lowers lipids, and everyone should be taking it," recalled Dr.