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A circular, double-stranded unit of DNA that replicates within a cell independently of the chromosomal DNA. Plasmids are most often found in bacteria and are used in recombinant DNA research to transfer genes between cells.


(Genetics) a small circle of bacterial DNA that is independent of the main bacterial chromosome. Plasmids often contain genes for drug resistances and can be transmitted between bacteria of the same and different species: used in genetic engineering
[C20: from plasm + -id1]


(ˈplæz mɪd)

a strand or loop of DNA that exists independently of the chromosome in bacteria and yeast and that is capable of genetic replication: used in recombinant DNA procedures as a vehicle of gene transfer.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.plasmid - a small cellular inclusion consisting of a ring of DNA that is not in a chromosome but is capable of autonomous replication
cellular inclusion, inclusion body, inclusion - any small intracellular body found within another (characteristic of certain diseases); "an inclusion in the cytoplasm of the cell"
References in periodicals archive ?
Linear DNA is a form of DNA distinct from the circular form of DNA most commonly produced in plasmids and grown in bacteria.
Under these Phase 1 CRO (Contract Research Organization) agreements, the performance of linear DNA will be benchmarked by criteria such as gene expression, and cell viability, against existing data from DNA produced using plasmids. LineaRx will also optimize, produce, and purify the products as required for testing both in vitro and in vivo by our customers.
LineaRx announced that it has improved expression levels and survival rates of linear DNA constructs delivered without viruses or plasmids to human T cells.
We conducted whole-genome sequencing for 68 Salmonella Anatum isolates from humans and animals and 9 isolates from chicken carcasses and abbatoir environments by using the Illumina MiSeq platform ( and identified resistance genes, incompatibility groups of plasmids, and sequence types by using the whole-genome sequencing data.
anthracis, plasmids containing capsular (CapB) and protective antigen (PA) (Christensen et al., 2006).
Broad Institute scientists deposit DNA-based materials called plasmids to Addgene, a global, nonprofit repository that allows scientists from various labs to conduct CRISPR genome editing in their own labs.
This article is the first report about the application of chaperone plasmids encoding Gro-EL, DnaJ, Tig, GroES, DnaK and GrpE chaperones to increase the soluble expression of anti-CD20-huscFv in E.
AAV manufacturing has traditionally required unique custom batches of helper plasmids. This can be expensive and time consuming.
Canonically horizontal gene transfer (HGT) is dependent on mobile genetic elements (MGEs) that include plasmids, transposons, bacteriophages, genomic islands, and integrative conjugative elements (ICEs).
Summary: TEHRAN (FNA)- Scientists have design better molecules that make it harder for plasmids to move between bacteria.
It also acts as a strong DNA-intercalating agent and biotechnologists use it widely as a potent plasmid curing agent wherein a bacterium is made free of plasmids.
If only one or a few plasmids are inserted into the cell, the new DNA could just be silenced.