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 (plī-ŏt′rə-pē) also plei·ot·ro·pism (-pĭz′əm)
n. Biology
The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

[Greek pleiōn, more; see pelə- in Indo-European roots + -tropism.]

plei′o·tro′pic (plī′ə-trō′pĭk, -trŏp′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(plaɪˈɒ trə pi)

the phenomenon of one gene affecting more than one phenotypic characteristic.
plei`o•trop′ic (-əˈtrɒp ɪk, -ˈtroʊ pɪk) adj.
plei`o•trop′i•cal•ly, adv.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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Genome-wide association of an integrated osteoporosis-related phenotype: Is there evidence for pleiotropic genes? J.
Psychiatrists should start conceptualizing DSM-5 disorders not as freestanding medical conditions but as syndromes--collections of inter-related clinical phenotypes resulting from pleiotropic genes. Given the extensive structural and neurochemical interconnectedness of brain cells, regions, and circuits, it is surprising that we have not approached psychiatric disorders in this fashion long ago, instead of falling in the trap of manufacturing artificially isolated mental disorders and then inventing the concept of "common comorbidity" to explain what we are seeing instead of seeking a genetic linkage between them.
It explains more than 20% of genetic variance (variation from pleiotropic genes excluded) in the Cd.