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Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

[New Latin polymyxa, specific epithet (poly- + Greek muxa, slime) + -in.]


(Pharmacology) any of several polypeptide antibiotics active against Gram-negative bacteria, obtained from the soil bacterium Bacillus polymyxa
[C20: from New Latin Bacillus polymyxa; see poly-, myxo-, -in]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.polymyxin - any of several toxic antibiotics obtained from a particular soil bacterium
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
Its resistance to colistin - a polymixin drug of last resort - is likely to quickly render this drug ineffective.
In Europe, 80 percent of polymixin sales -- mainly colistin -- are in Spain, Germany and Italy, according to the European Medicines Agency's Surveillance of Veterinary Antimicrobial Consumption (ESVAC) report.
In addition, all isolates were resistant to nalidixic acid and had intact VC_1577 (almG), VC_1578 (almF), and VC_1579 (almE) genes, which have recently been shown to explain the genetic basis for resistance to polymixin B/nalidixic acid (27).
1% Spersadex Prednisolone acetate 1% Pred Forte 18-36 40 Combined preparations Betamethasone, neomycin Betnesol N 36-54 Dexamethasone, Covomycin D 36-54 chloramphenicol Fluoromethalone, FML-Neo neomycin Dexamethasone, Maxitrol 36-54 neomycin, polymyxin B Dexamethasone, Sofradex 36-54 framycetin, gramicidin Dexamethasone, Spersadex Comp 36-54 chloramphenicol Hydrocortisone, Terra-Cortril 12-Aug oxytetracycline, polymixin B Dexamethasone, Tobradex 36-54 tobramycin Drugs in order of increasing potency Side-effect Indications Single preparations Prednisolone Worsening Allergic acetate 0.
On the other hand, it was reported that use of broad-spectrum antibiotics including trimethroprim, polymixin B may be efficient, since it shortened the course of the disease (55).
We have become reliant on colistin, a nephrotoxic polymixin antibiotic developed in the 1960s.
Histamine liberation by codeine and polymixin B in urticaria pigmentosa.
Then there are others which involve all classes of drugs except the polymixin group of drugs (5).
The high mortality rate in ICU patients (22% to 59%) necessitates effective treatment with the less-common polymixin antibiotics.
Furthermore, the addition of polymixin B (5 mg/L) (16) did not alter any of the effects observed with CRP.