polymyxin

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pol·y·myx·in

 (pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

[New Latin polymyxa, specific epithet (poly- + Greek muxa, slime) + -in.]

polymyxin

(ˌpɒlɪˈmɪksɪn)
n
(Pharmacology) any of several polypeptide antibiotics active against Gram-negative bacteria, obtained from the soil bacterium Bacillus polymyxa
[C20: from New Latin Bacillus polymyxa; see poly-, myxo-, -in]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.polymyxin - any of several toxic antibiotics obtained from a particular soil bacterium
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
(3,4,10) Bacitracin is available in combination with polymixin B and/or neomycin OTC in the United States, and while this OTC product appears to have good laboratory data to support its effectiveness against Gram-positive bacteria, it has not stood the test of clinical applicability and is feared to not effectively eradicate bacteria.
Aminoglycosides, polymixin B, quinolones, and acetic acid are generally used as topical antimicrobial agents.
Notable among the drugs under development against KPC are mostly derivatives of polymixin, [beta]-lactamase inhibitor NXL104 with combination of oxyimino cephalosporin as well as with ceftazidime [6].
Treatment of equine endometritis with intrauterine irrigations of Ceftiofur sodium: A comparison with mares treated in a similar manner with a mixture of sodium benzylpenicillin, neomycin sulfate, polymixin B sulfate and furaltadone hydrochloride.
Successfully isolated [beta]-hemolytic colonies were subjected to a series of tests to confirm traits characteristic of MRSA including Gram staining for G(+) cocci cluster morphology, positive assay results for catalase and coagulase production (both tube and slide for the latter), and antibiotic resistance in the presence of polymixin B.
Fosfomycin, tigecycline, polymyxin B, and colistin are the last-line-of-defense therapies against CRGNBs, but some bacteria are resistant to fosfomycin; polymixin B has limited therapeutic scope; some carbapenem-resistant bacteria are also intrinsically resistant to colistin; and there have been reports recently of tigecycline-related and polymxin B-related deaths.
Many drugs like aspirin, NSAIDs, Polymixin B, ACE inhibitors etc.
Its resistance to colistin - a polymixin drug of last resort - is likely to quickly render this drug ineffective.
In Europe, 80 percent of polymixin sales -- mainly colistin -- are in Spain, Germany and Italy, according to the European Medicines Agency's Surveillance of Veterinary Antimicrobial Consumption (ESVAC) report.