Additional studies are ongoing or planned to assess its potential for a solid tumour indication and in other malignant and pre-malignant
diseases in which CD38 is expressed, such as smouldering myeloma.
Gordon Early and Betty Abernathy, RN offer Family Medical Care and additional services such as Clinical and Consultative Services, Medicare Annual Wellness Exams, Gynecological Exams and Pap Smears, Minor Orthopedic Care Including Minor, Extremity Fractures, Suture repair, FAA Physicals, Cryotreatment of warts and pre-malignant
skin lesions, Sports Physicals.
Currently, five Phase III clinical studies with daratumumab in relapsed and frontline multiple myeloma settings are ongoing and additional studies are ongoing or planned to assess its potential in other malignant and pre-malignant
diseases on which CD38 is expressed, such as smouldering myeloma, NKT-cell lymphoma, amyloidosis, myelodysplastic syndromes and solid tumours.
Among them many lesions are benign, pre-malignant
and malignant with various aetiological factors.
The use of toluidine blue in the detection of pre-malignant
and malignant oral lesions.
7% presented with malignant or pre-malignant
Prevalence of oral pre-malignant
and malignant lesions at a tertiary level hospital in Allahabad, India.
Oral sub mucous fibrosis is considered to be a pre-malignant
condition characterized by tightening of mucosa due to formation of fibrous bands which run vertically across the oral mucosa and results in limited mouth opening.
Despite the concept by people that routine histopathology of cholecystectomy plays a dismal role in the management of most patients3, it plays an important role in clinicopathologic correlation of various lesions of gall bladder and helps in diagnosing pre-malignant
condition like porcelain gall bladder or malignant conditions like carcinoma in situ and early carcinoma.
The study also suggested that measuring the editing levels in patient gastric samples, which can be obtained through a simple biopsy, particularly at the pre-malignant
stage, may help in identifying individuals at risk for subsequent gastric cancer development.
Colon cancer has a pre-malignant
phase so it's very important.
It can take a decade for a pre-malignant
lesion to progress into an invasive cancer.