Prospective separation of residual HSCs from leukemia cells coupled with exome sequencing allow the investigation of preleukemia
subclones and the identification of the order of mutations in AML.
The clinical and biological dilemma of preleukemia
presenting as aplastic anemia with chromosomal translocation t(4;11).
I have preleukemia
in my bone marrow" she told her viewers.
The diagnosis was MDS - myelodysplastic syndrome - sometimes called preleukemia
following large dose radioiodide therapy for metastatic thyroid carcinoma.
Incidence of acute nonlymphocytic leukemia, preleukemia
, and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin's disease.
Specifically, peripheral blood during preleukemia
phase, bone marrow aspiration and biopsy may not be sufficient for diagnosis.
11 June 2010 - Danish biotech company Topotarget A/S (CPH: TOPO) has started a phase I study with its product belinostat in combination with Velcade (bortezomid) for the treatment of acute leukemia or myelodysplastic syndromes (MDS), formerly known as preleukemia