They found that their monoclonal antibodies reacted to an intermediate, or "oligomer" state of the amyloid and tau proteins seen in Alzheimer's disease, as well as to prion disease
But evolution had already devised a cure for the prion disease
, a new study shows.
In 2008, a novel prion disease
, initially referred to as protease-sensitive prionopathy, was reported in 11 patients who had been referred to the National Prion Disease
Pathology Surveillance Center (Cleveland, OH, USA) during May 2002-January 2006.
A prion disease
called Bovine Spongiform Encephalopathy (BSE) is endemic to cows.
The topics range from the suspected neuroprotective role of the non-prion PrPC protein in the brain to the inflammation caused by prion aggregates, molecular mechanisms used by prions, attempts to protect against prion transmission, attempts to develop antibody-based vaccines and therapies for prion diseases
, and the clinical aspects and classification of human prion disease
The genetic focus of prion disease
lies in the Prnp gene, which is located on chromosome 20 in humans and is a member of the Prn gene family.
Their loved ones had been subjected to extensive and costly evaluations for other conditions, and the families had failed to be protected from a transmissible prion disease
British researchers writing in the journal Nature said they had found a major pathway leading to brain cell death in mice with prion disease
, the mouse equivalent of Creutzfeld-Jacob Disease (CJD).
Centers for Disease Control and Prevention, "Classic CJD is a human prion disease
The ability of [this assay] to detect prions in plasma samples raises the possibility that this assay could be used to improve prion disease
diagnosis in humans and animals and to screen the blood supply for prion contamination," wrote Dr.
A specialist in brain phospholipases, lipid mediators, glutamate neurotoxicity, and neurological disorders, Farooqui summarizes the current knowledge about neurochemical aspects of trauma such as stroke and head injury and disease such as Alzheimer's and prion disease
A cohort study of the impact of prion disease
on farm family community health (Rural Family Health) is currently underway, led by Wilfreda E.