prodrug

(redirected from Pro-drug)
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pro·drug

 (prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

(ˈprəʊˌdrʌɡ)
n
(Biochemistry) a compound that is itself biologically inactive but is metabolized in the body to produce an active therapeutic drug

pro•drug

(ˈproʊˌdrʌg)

n.
an inactive substance that is converted to a drug within the body by the action of enzymes or other chemicals.
References in periodicals archive ?
We also met a significant milestone during the quarter in initiating the Phase 1 program for ZYN001, a pro-drug of THC delivered via patch, and expect to initiate our Phase 2 program by the end of this year.
The pancreatic cancer treatment includes implanting living cells that have been encapsulated in pin-head sized, cellulose-based, protective cocoons through the use of the Cell-in-a-Box technology, followed by the administration of low doses of the anti-cancer pro-drug, ifosfamide.
Summary: According to the pro-drug lobby -- and with a boost from the media -- Uruguay is leading the world by legalizing marijuana.
Their topics include the chemical synthesis of acyclic nucleosides, mononucleotide pro-drug synthetic strategies, synthesizing conformally constrained nucleoside analogues, stereoselective methods in synthesizing bioactive oxathiolate and dioxolane nucleosides, and synthetic studies on antifungal peptidyl nucleoside antibiotics.
Pharmacologic ascorbate can act as a pro-drug for hydrogen peroxide (H(2)O(2)) formation, which can lead to extracellular fluid at concentrations as high as 200 [micro]mol/L.
They address platforms and technologies at different stages of clinical and preclinical development, including active targeting, nucleic acid delivery and targeting, intracellular/organelle-specific strategies, pro-drug strategies, organ or tissue-specific drug delivery, drug-polymer conjugates and micelles, and stimuli-responsive systems.
Medical treatment of feline hyperthyroidism has traditionally involved daily use of the azole drugs, methimazole or its pro-drug, carbimazole (many cats require twice daily treatment with these drugs).
Simeonidis expects INNO-206 to be a very large product as it is a pro-drug to doxorubicin, a common cancer treatment that has sales in hundreds of millions of dollars.
This case began with a silly nonsensical banner, (and) ends with the court inventing out of whole cloth a special First Amendment rule permitting the censorship of any student speech that mentions drugs, so long as someone could perceive that speech to contain a latent pro-drug message.
Based on the social influence model of prevention, Project ALERT is designed for middle school adolescents and has been proven effective in curbing cigarette and marijuana use, mitigating alcohol misuse, and reducing pro-drug attitudes in two large-scale, multisite trials--one that included 3,800 students from 30 schools in two Western states (Ellickson & Bell, 1990; Ellickson, McCaffrey, Ghosh-Dastidar, & Longshore, 2003; Ghosh-Dastidar, Longshore, Ellickson, & McCaffrey, 2004).
TAFA93, a pro-drug rapamycin, is a novel small molecule mTOR inhibitor, which is typically used in combination with calcineurin inhibitors after organ transplant.