probucol


Also found in: Medical, Wikipedia.
Related to probucol: Lorelco
Translations

probucol

n probucol m
References in periodicals archive ?
The exclusion criteria were: 1) secondary hypertension; 2) taking lipid-regulating agents such as statins, niacin, probucol, or fibrates; 3) coronary heart disease; 4) arrhythmia; 5) heart failure; 6) diabetes mellitus; 7) peripheral artery disease; 8) primary hyperthyroidism or hypothyroidism; 9) known intolerance or hypersensitivity to HMG-CoA reductase inhibitors; 10) alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels > 2-fold the upper normal limit; 11) serum creatinine >178 [micro]mol/L or creatine kinase (CK) > 3-fold the upper normal limit; 12) Behcet disease, or 13) psoriasis.
Probucol alone or in combination with antioxidant vitamins seems to be effective in reduction of subsequent restenosis rates (Tardif et al.
Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy.
For example, [beta]-caryophyllene, a constituent in oregano at very low levels, has a higher inhibitory capacity on lipid peroxidation than probucol, [alpha]-humulene, and [alpha]-tocopherol [31, 32].
Impact of short-duration administration of N-acetylcysteine, probucol and ascorbic acid on contrast-induced cytotoxicity," Journal of Nephrology, vol.
Probucol protects against gentamicin induced nephrotoxicocity in rats.
Many clinical drugs that against cardiovascular diseases have exhibited antioxidant effects; these drugs simultaneously inhibit endothelial adhesion molecule expression, such as aspirin, probucol, HMG-CoA reductase inhibitors, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, peroxisome proliferator-activated receptor alpha and gamma ligands, calcium channel blockers, beta-adrenergic blockers, etc.
The major activator, probucol, which has been wrongly labeled as an antioxidant and antiinflammatory agent, has a clear stimulatory effect on the CETP system, as our group first showed in 1989 (15).