Also found in: Medical, Wikipedia.
Related to proguanil: mefloquine


A drug, C11H16ClN5, used in its hydrochloride form as an antimalarial, usually in combination with atovaquone.

[pro(pyl) + guan(idine) + alteration of -yl.]


n proguanil m
References in periodicals archive ?
While quinine was isolated from the bark of the cinchona tree in 1820, chloroquine, proguanil, mefloquine, and atovaquone each were developed during or after a military conflict during 1945-1985.
Sold under the brand name Maloff Protect,l the tablets contain two antimalarial agents, atovaquone and proguanil.
La combinacion de atovacuona mas proguanil tambien actua sobre las formas hepaticas en desarrollo (trofozoitos), pero no tiene accion contra los esporozoitos ni contra los hipnozoitos (7,8) (figura 1).
14) However, using the same model, the prophylactic combination of proguanil plus sulfamethoxazole was found not to be causally prophylactic.
In addition to metabolizing drugs and developing inactive metabolites, it is also activated in the activation process of some effective medications, including the conversion of proguanil anti-malaria drug into cycloguanil (13), conversion of tamoxifen to the two active metabolites including 4-hydroxy tamoxifen and 4-hydroxy methyl-N-dose tamoxifen (14) and the conversion of clopidogrel at first to its active form and then into 2-oxo-clopidogrel (15,16).
After laboratory confirmation of malaria diagnosis, the therapy was changed to a 3-day course of atovaquone and proguanil.
Atovaquone/Proguanil (Malarone) is a combination of the atovaquone mentioned above (Mepron) in a tablet form combined with proguanil.
Los demas tratamientos antimalaricos evaluados se administraron en un porcentaje inferior a 10%, estos resultados son similares a los reportados en estudios en la poblacion general, pero diferentes al manejo realizado en poblaciones militares en diferentes partes del mundo, donde hay mayor porcentaje de utilizacion de doxiciclina oral y atovaquona proguanil como primera linea de tratamiento (2).
Proguanil, 200mg daily, is recommended additionally in the high risk regions [26].