The main prokinetic
agent, metoclopramide, works much better in liquid form than in pill form, he said.
These results suggest that HKT improves delayed gastric emptying and acts as a prokinetic
Pharmacologic options include laxatives, prokinetic
drugs, and other therapies.
I would also consider adding a prokinetic
agent, because reflux is more of an esophageal motility problem, not an acid problem.
In addition to antimicrobial and anti-inflammatory effects, it is possible that extraluminal manifestations of GERD (wheezing) were being ameliorated by the prokinetic
action (enhanced gastric emptying) of the macrolide antibiotic.
The combination of the prokinetic
medication cisapride and the antidepressants fluvoxamine and nefazodone is of particular concern.
Cisapride is a substituted benzamide compound that stimulates motor activity in all segments of the gastrointestinal tract by enhancing the release of acetylcholine from the enteric nervous system Actions at enteric neuronal serotonin (5-hydroxytryptamine-[5-HT]) receptors have been implied in the prokinetic
effects of cisapride.
Peter Stein, Chairman and CEO of Norgine said, "There is a critical need for a new, safe and effective prokinetic
drug for use in acute care settings, as there are no satisfactory treatments on the market.
He had initial feeding difficulties with intermittent vomiting which responded to prokinetic
Medical Futures is focused on gastroenterology, pain control and women's heath with products including Florastor, an anti-diarrheal probiotic, Iberogast, an all natural prokinetic
medicine containing nine herbal extracts, Mutaflor, a probiotic that normalises stool frequency and consistency in both diarrhea and constipation, and Proferrin, an iron supplement.
Initial treatment is with lifestyle modifications and proton pump inhibitors; prokinetic
medications may be required in selected patients.