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 (prō′tə-mēn′, -mĭn) also pro·ta·min (-mĭn)
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.


(Biochemistry) any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish
[C19: from German: see proto-, amine]


(ˈproʊ təˌmin, prɒˈtæm ɪn)

any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat.
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Noun1.protamine - a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
simple protein - a protein that yields only amino acids when hydrolyzed
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References in periodicals archive ?
Using a quantitative biochemical approach, I will test the possibility that nucleosome retention at CpG islands is an indirect consequence of high intrinsic affinities of protamines for GC-poor DNA.
The replacement of histones with protamines is a crucial step in spermatogenesis.
During the later stages of spermatogenesis, the spermatid nucleus is remodelled and condensed, which is associated with the displacement of the majority of histones (85%) by transition proteins and then by protamines (50).
Sperm DNA is bound to protamines and thus is highly compact and condensed, however, about 15 per cent DNA is bound to histones and is peripherally located in the nucleus and is susceptible to environmental insults especially oxidative damage.
In a second study, Mohamed Hammadeh from the University of the Saarland in Germany, and colleagues, examined the concentrations of two proteins called protamines P1 and P2, which are crucial to the formation of chromosomes during cell division.
A second study in Germany looked at the levels of two protamines - P1 and P2 - in the sperm of smokers and non-smokers.