Robin's scientific focus is innovative approaches to small molecule drug discovery, specifically fragment-based discovery, DNA encoded libraries, covalent drug discovery, protein degradation
and the integration of chemical technologies in into structure and predictive modelling-based drug design.
The company is a leader in the "underappreciated" field of targeted protein degradation
with optionality from multiple near-term oncology clinical readouts, Merle tells investors in a research note.
"This is the first time that we have described a surprising connection between protein degradation
and the development of resistances against taxanes and other drugs that act on the spindle microtubules," said Hoffmann.
"Structural basis of PROTAC cooperative recognition for selective protein degradation
"This innovative strategy of controlling protein proximity to enable targeted protein degradation
represents a powerful approach to potentially develop therapeutics for what have been otherwise intractable diseases of the brain," says Stephen J.
(NASDAQ: GILD) and Nurix Therapeutics, Inc., a company discovering drugs that harness the body's natural process to control protein levels, have forged a global strategic collaboration to discover, develop and commercialise a pipeline of innovative targeted protein degradation
drugs for patients with cancer and other challenging diseases, the companies said.
Decline of protein content may be due to inhibition of protein synthesis or protein degradation
Microbial, physicochemical and protein degradation
analyses were performed in triplicate on the 0, 3, 6, 9, and 12 of storage period.
On the other hand, the exact mechanism by which protein degradation
affects skeletal muscle mass and meat productivity is less understood.
"C4T's platform enables the discovery of novel molecules that take advantage of endogenous protein degradation
mechanisms to target disease-causing proteins," said Michael Ehlers, executive vice president, research and development, Biogen.
5) They inhibit tissue-damaging reactive oxygen species (ROS) formed during exercise that can cause protein degradation
They increase protein synthesis, decrease protein degradation
and cause a net increase in myofibrillar protein content5.