protein kinase


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Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

n.
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.
References in periodicals archive ?
France-based biopharmaceutical company Poxel SA (Euronext: POXEL - FR0012432516) has initiated a PK/PD study, which is part of the Phase 2a clinical programme for PXL770, a first-in-class direct adenosine monophosphate-activated protein kinase activator, for the treatment of NASH, the company said.
AMP activated protein kinase (AMPK) is a cellular energy sensor that can be activated by adding phosphate group as a consequence to metabolic stress that depletes ATP (contraction of muscle) or prevents ATP assembly (glucose deficiency, ischemia and hypoxia) and so increases the AMP:ATP ratio.3 It is known that AMPK inhibits mostly all anabolic activities which help cells proliferation and consequently inhibits tumor growth and development.4 Once motivated, p-AMPK controls energy-diminishing processes like cellular proliferation and stimulates energy producing reaction like lipid oxidation, glucose uptake and glycolysis.
Based on the molecule on which kinases act, they can be categorized as: protein kinase, lipid kinase, carbohydrate kinase and other kinase (thymidine kinase and riboflavin kinase).
Seven genes with LRR receptor-like serine/threonine kinase that encode protein kinase & LRR domain were classified into Class 4 and out of these seven genes, six have an additional malectin domain and based on a study, a malectin-like leucine-rich repeat receptor-like kinase in Arabidopsis contributes to downy mildew disease resistance (30).
The study, which was published July 2 in Nature Medicine, found that, in people with idiopathic pulmonary fibrosis, AMP-activated protein kinase (AMPK) is lower in certain cells within the fibrotic regions of lung tissue.
ATI-450, an investigational drug, is a selective inhibitor of p38 mitogen-activated protein kinase-activated protein kinase 2 interface and an attractive candidate for stromal-targeted therapy.
She added:"Metformin upregulated activated protein kinase (AMPK) in breast adenocarcinoma resulting in subsequent inhibition of the mammalian target of rapamycin (mTOR).
The [Ca.sup.2+]/calmodulin- (CaM-) dependent protein kinase II (CaMKII) is an ideal regulator of synaptic plasticity because it has complex autoregulatory features that make it ideally suited for regulating activity-dependent plasticity [4-7].
Protein Kinase CK2 Cellular Function in Normal and Disease States: Springer; 2015.
We also set out to understand the molecular mechanisms involving the activity of the insulin receptor (IR), the IR substrates 1 and 2 (IRS1/2), the phosphoinositol-3-kinase protein (PI3K), and protein kinase B (Akt/PKB), and the regulation of glucose transporter isoform 4 (GLUT4) in response to acute and chronic resistance exercise.
Lurie Children's Hospital of Chicago found that these tumours' growth and tendency to metastasize are regulated by a protein kinase called Polo-like kinase 4 (PLK4), which is increased in AT/RT.
The acquired ataxia telangiectasia and Rad3-related protein kinase inhibitor program covers two clinical-stage compounds, VX-970 and VX-803.
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