oncogene

(redirected from Protooncogene)
Also found in: Thesaurus, Medical, Encyclopedia.

on·co·gene

 (ŏn′kə-jēn, ŏng′-)
n.
1. Any of various mutated genes that cause the transformation of normal cells into cancerous cells.
2. Any of various viral genes that transform host cells into cancerous cells.

[Greek onkos, mass, tumor; see oncology + gene.]

oncogene

(ˈɒŋkəʊˌdʒiːn)
n
(Genetics) any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
[C20 from Gk onkos mass, tumour + gene]

on•co•gene

(ˈɒŋ kəˌdʒin)

n.
any gene that is a causative factor in the initiation of cancerous growth.
[1965–70]

on·co·gene

(ŏn′kə-jēn)
A gene containing a mutation in its DNA that causes normal cells to turn into cancerous ones. See Note at cancer.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oncogene - a gene that disposes normal cells to change into cancerous tumor cellsoncogene - a gene that disposes normal cells to change into cancerous tumor cells
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Translations
References in periodicals archive ?
Differential hypomethylation of the c-myc protooncogene in bladder cancers at different stages and grades.
Antisense mediated inhibition of Bcl-2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxy-nucleotides.
This "protooncogene" spurs normal cell growth and differentiation in a wide range of tissues.
MET, or hepatocyte growth factor receptor, is a tyrosine kinase and protooncogene associated with NSCLC.
Other stemness-linked markers lysine acetyltransferase 6A (MYST3), RE1-silencing transcription factor (REST), and SKI-like protooncogene (SKIL) were differentially modulated between hPDLSCs and MS-hPDLSCs.
Research has demonstrated that PELP1 is a protooncogene in hormone-responsive cancers, such as breast [19,20], ovarian [21], endometrial [22,23], and prostate cancers [24].
Fleischmann et al., "Protooncogene expression in porcine myocardium subjected to ischemia and reperfusion," Circulation Research, vol.
Essentially, miRNA deregulation in cancer is oncogenic (oncomiR) under two different conditions: (a) when overexpressed, miRNAs may block tumor suppressor gene translation or (b) when underexpressed, miRNAs may derepress protooncogene mRNA translation (Figure 2).
For a cell to acquire tumor phenotype, loss of TSG function is required, which may or may not be accompanied by over expression of protooncogene and there is also accumulation of additional mutations in other genes (5,6).
Early alterations in ras protooncogene mRNA expression in testosterone and estradiol-17 beta induced prostatic dysplasia of Noble rats.
As models, we chose 3 translocations, IGH-BCL2, MYC-IGH, and BCR-ABL1, characteristic translocations in follicular lymphoma (FL), Burkitt lymphoma (BL) and CML, respectively (gene information: IGH: immunoglobulin heavy chain; BCL2: BCL2, apoptosis regulator; MYC, MYC protooncogene, bHLH transcription factor).
(3) Patients with activating mutations of the KRAS protooncogene have constitutive activation of the MAPK pathway and are unresponsive to EGFR inhibition.