Over time, the pulmonary vascular resistance
increases, and the magnitude of the left-to right intracardiac shunting decreases; eventually, the shunt may become right to left with the development of arterial hypoxemia (Cyanosis) leading to Eisenmenger's syndrome.
High flow oxygen may reduce pulmonary vascular resistance
and magnify the coronary steal phenomenon.
Pulmonary vascular resistance
is chronically elevated in pulmonary arterial diseases such as scleroderma, idiopathic pulmonary hypertension (IPAH--previously called primary pulmonary hypertension) and chronic thromboembolism.
All had mPAPs greater than 25 with elevated pulmonary vascular resistances
Children with ASD typically have normal pulmonary vascular resistance
, and generally endure increased pulmonary blood flow which may exceed twice the systemic blood flow.
One study showed that treatment with bosentan was safe and led to improvements in pulmonary vascular resistance
and other measures, Dr.
Both agents showed no significant difference on right ventricular contractility or pulmonary vascular resistance
21 in order to assure increased pulmonary vascular resistance
and help balance pulmonary and systemic blood flow in patients with single ventricle physiology.
1) The clinical features includes Cardiac Arrhythmias, increased Pulmonary vascular resistance
(PVR) and Cardiac arrest.
Persistent pulmonary hypertension of the newborn is a cardiopulmonary disorder that is characterized by increased pulmonary vascular resistance
and systemic arterial hypoxemia.
BNP levels directly correlated with age, serum creatinine level, lactic dehydrogenase level, tricuspid regurgitant jet velocity, and pulmonary vascular resistance
, and inversely correlated with hemoglobin level, cardiac output, and 6-minute walk distance.
2[alpha]], produces severe hypertension, tachycardia and increased pulmonary vascular resistance