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 (po͝ol′mə-zīm′, pŭl′-)
A trademark for the drug dornase alfa.
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Geographies covered: US Germany France Italy Spain UK Japan Australia Canada Drugs covered Orkambi Pulmozyme Kalydeco Symdeko (Tezacaftor + Ivacaftor) Tobramycin VX-659 + Tezacaftor + Ivacaftor VX-152 + Tezacaftor + Ivacaftor VX-440 + Tezacaftor + Ivacaftor QR-010 ABBV-2222 GLPG1837 Disease Indication Overview: This section of the report gives the overview of Cystic Fibrosis disease indication in detail.
Dornase alfa is sold under the brand name Pulmozyme in the US and the EU and was first approved for treatment of cystic fibrosis in the US in 1993 and in Europe in 1994.
Recombinant human deoxyribonuclease (rhDNAse (Pulmozyme)) [33] and glucocorticoids [34] are not recommended in the management of infants and children with bronchiolitis.
At present inhalation has proven to be best suited for the treatment of locoregional conditions using macromolecules such as Pulmozyme and Promixin.
John has filled his prescription for Pulmozyme at his local pharmacy.
The Swiss drugmaker already markets Pulmozyme for cystic fibrosis and Xolair for severe asthma in the United States, and has other experimental respiratory products in clinical development, including another severe asthma drug called lebrikizumab.
The 1990s saw the introduction of the drug Pulmozyme to improve clearance of bronchial secretions (7).
103532 Pulmozyme (dornase alfa) Inhalation Solution MACMIS ID #17309, FDA.GOV (Apr.
Acetylcysteine (Mucomyst) and guaifenesin are also helpful, but dornase alfa (Pulmozyme) is not indicated in non-CF patients and was actually harmful in one study.
The purpose of this article is to give a brief overview of how the drug dornase alfa (Pulmozyme (R), Genentech) affects CF, as well as how it is administered, its side effects and case studies.