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Noun1.Purkinje - Bohemian physiologist remembered for his discovery of Purkinje cells and the Purkinje network (1787-1869)Purkinje - Bohemian physiologist remembered for his discovery of Purkinje cells and the Purkinje network (1787-1869)
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He is also Lead Director of EXFO Inc., Lead Director of Alithya and Lead Director of Purkinje Inc.
(12) on cerebellar purkinje neurons, it was reported that cells were depolarized in a mean value interval of approximately 0.30-2.50 mV with the inhibition of ERG channels by specific blockers but this effect was not statistically significant.
Gestational diabetes induces a loss in number and size of the Purkinje cells (Neuron purkinjense) and the granular cells in the rat cerebellum in early postnatal life (Razi et al., 2015).
MB-originated ventricular tachycardia or ventricular fibrillation (VT/VF) is a kind of idiopathic malignant arrhythmia in the absence of structural heart disease, which is frequently triggered by a premature ventricular contraction (PVC) from the same site.[1] As the mechanism of this kind of arrhythmia is not well illustrated, previous research has reported the involvement of the Purkinje system of the right ventricle (RV), although catheter radiofrequency (RF) ablation delivered to the site displaying Purkinje potential showed limited efficacy.[2],[3] Herein, we present a case of MB-originated VT/VF in a 29-year-old woman in whom ablation based on the anatomical substrate (free wall and septum insertions of MB) proved successfully.
"There were several mouse models of TSC previously published, but they all had seizures and died early in life, making it difficult to study social cognition."That is one reason why we turned to knocking out the TSC1 gene only in cerebellar Purkinje cells, which have been implicated in autism.
The histogenesis of rhabdomyoma is still uncertain, some authors suggest that they are hamartomas (ROBINSON & ROBINSON, 2016), while others have investigated whether the cells are derived from the striated myocardium (COOPER & VALENTINE, 2017) or Purkinje fibers (TANIMOTO & OHTSUKI, 1995).
The highest virus load (by real-time PCR) was found in the central nervous system, and lesion-associated Purkinje cells and neurons of the granular cell layer of the cerebellum showed positive FISH results (Figure 1, panel B).
The KCNMA1 gene encodes the a-subunit of the large conductance, voltage, and calcium-sensitive potassium channel (BK channels), which is also activated by the concentration of cytosolic [Mg.sup.2+] and is known to be predominantly expressed in the amygdala, caudate nucleus, cerebral cortex, hippocampus, hypothalamus, spinal cord, and Purkinje cells in the cerebellum (1,2).
Necropsy revealed severe pancreatic atrophy and fibrosis with regionally extensive cerebellar encephalomalacia and generalized Purkinje cell degeneration and necrosis.
As part of their recent investigations, published May 16 in the journal Nature, Ackerman, Paul Schimmel (Scripps Research Institute) My-Nuong Vo (Scripps Research Institute) and Markus Terrey (UC San Diego) identified that Ankrd16 rescued specific neurons -- called Purkinje cells -- that die when proofreading fails.
The study, published in the journal Nature, showed that the new gene 'Ankrd16' rescued specific neurons-called Purkinje cells-that die when the proofreading fails.
In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like features.