pyrazole


Also found in: Wikipedia.

pyrazole

(ˈpaɪrəˌzəʊl)
n
(Elements & Compounds) a crystalline soluble basic heterocyclic compound; 1,2-diazole. Formula: C3H4N2
[C19: from German, from pyrrole + inserted -az- (see azo-)]
Translations
pyrazole
Mentioned in ?
References in periodicals archive ?
With the optimal reaction conditions in hand, we then synthesized the selected barbiturate and thiobarbiturate derivatives by treating aldehydes [3-(p-methoxy) pyrazole aldehyde, 2-chloro quinoline aldehyde, Indole-3-carboxaldehyde and N,N-dimethyl benzaldehyde] with active methylene group containing compounds as barbituric acid, thiobarbituric acid and dimedone using1-butyl-3-methylimidazolium hydroxide (2 mL) as solvent medium.
* Deng XL, Zhang L, Hu XP, Yin B, Liang P Yang XL (2016) Target-based design, synthesis and biological activity of new pyrazole amide derivatives.
(2008) recommended 3,4-dimethyl pyrazole phosphate (DMPP) due to its documented benefits on both crop yield and N loss, and its stability and lack of movement in soil.
Figure 2: Example of molecular structure: 3-(methylamino) pyrazole
Alam's research work includes three recent grants funded through the Arkansas IDeA Network of Biomedical Research Excellence, two involving novel pyrazole compounds and an instrumentation grant for cryogenic storage for mammalian cells.
Bhusare, "Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents," Arabian Journal of Chemistry, 2015.
The pyrazole ring is a structural isomer of imidazole; pyrazole name comes from the pyrrole ring to which a nitrogen atom was added: "azole." The two nitrogen atoms have different properties: one behaving like pyridine can undergo protonation in an acid medium; the other has the property of the pyrrole nitrogen doublet participating in the aromaticity of the ring [16].
Galli, "Coordination polymers and metal-organic frameworks based on poly (pyrazole)-containing ligands," Coordination Chemistry Reviews, vol.
Besides, pyrazole derivatives have been of great interest in medicinal chemistry for their role as potent antiparasitic [13], antimicrobial [14], and antitumor agents [15].
Previous studies demonstrated its inhibition by curcumin and its structurally related bisdemethoxycurcumin (GG6), both carrying the hepta1,4,6-trien-3-one scaffold, whereas the GG6-based pyrazole analogue (GG9) was inactive [13].
Since 2000, several new non-repellant soil termiticides have been introduced on the market, such as Fipronil, a phenyl pyrazole (Aventis Corp, 2001), Imidacloprid, a chloronicotinyl (Bayer Corp, 2000), and Chlorfenapyr, a pyrrole (BASF Corp, 2001).