pyrimidine

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py·rim·i·dine

 (pī-rĭm′ĭ-dēn′, pĭ-)
n.
1. A single-ringed, crystalline organic base, C4H4N2, that is the parent compound of a large group of biologically important compounds.
2. Any of a group of substituted derivatives of pyrimidine, including the nitrogen bases uracil, cytosine, and thymine, which are components of nucleic acids. Barbiturates and certain other drugs are also pyrimidines.

[Alteration of pyridine.]

pyrimidine

(paɪˈrɪmɪˌdiːn)
n
1. (Elements & Compounds) a liquid or crystalline organic compound with a penetrating odour; 1,3-diazine. It is a weakly basic soluble heterocyclic compound and can be prepared from barbituric acid. Formula: C4H4N2
2. (Elements & Compounds) Also called: pyrimidine base any of a number of similar compounds having a basic structure that is derived from pyrimidine, including cytosine, thymine, and uracil, which are constituents of nucleic acids
[C20: variant of pyridine]

py•rim•i•dine

(paɪˈrɪm ɪˌdin, pɪ-)

n.
1. a heterocyclic compound, C4H4N2, that is the basis of several important biochemical substances.
2. one of several pyrimidine derivatives, esp. the bases cytosine, thymine, and uracil, which are fundamental constituents of nucleic acids.
[1880–85;b. pyridine and imide]

py·rim·i·dine

(pī-rĭm′ĭ-dēn′)
Any of a group of organic compounds having a single ring with alternating carbon and nitrogen atoms. Pyrimidines include the bases cytosine, thymine, and uracil, which are components of nucleic acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.pyrimidine - any of several basic compounds derived from pyrimidine
alkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"
cytosine, C - a base found in DNA and RNA and derived from pyrimidine; pairs with guanine
T, thymine - a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine
2.pyrimidine - a heterocyclic organic compound with a penetrating odor
organic compound - any compound of carbon and another element or a radical
Translations
pyrimidine
References in periodicals archive ?
Protozoa are unable to synthesize purines or pyrimidines, but can incorporate free adenine, guanine and uracil into their nucleic acids.
Summary: 5-Substituebenzoyl-4-aryl-6-substituephenyl-1,2,3,4-tetrahydro-2-(thioxo, oxo and imino) pyrimidines (4a-d) were synthesized via multicomponent cyclocondensation reaction.
The nitrogenous bases Purines [adenine (A) and guanine (G)] and Pyrimidines [Cytosine (C), Uracil (U)and Thymine (T)] are essential building blocks of RNA and DNA.
Antifungal drugs (azoles, pyrimidines, echinodians, polyenes, allylamines, and other antifungal drugs)
The pyrimidine bases are the part of the nucleic acids, and therefore, both natural pyrimidines and pyrimidine derivatives have diverse effects on the body.
For presentation purposes, metabolites were classified into 11 categories (see online Supplemental Tables 7 and 8): lipids and lipid metabolites (n = 118); bile acids (n = 5); amino acids (n = 22); amino acid derivatives (n = 28); amines (n = 7); alcohols (n = 3); carbohydrates and intermediates (n = 13); organic acids (n = 17); purines, pyrimidines, and derivatives (n = 28); vitamins (n = 7); and other (n = 9).
As a potent inhibitor of dihydrofolate reductase, the rate-limiting enzyme in the production of tetrahydrofolate, it decreases the de novo production of purines and pyrimidines and interferes with DNA synthesis.
Additionally, if two non-complementary strands try to pair up any two purines, they're physically too large to both fit between the backbones; and if two pyrimidines are placed across from each other, they're too small and their respective H-bond donors and acceptors not only don't match up, but are also too far apart to effectively interact.
In good agreement with the key role of RutR in synthesis and degradation of pyrimidines, both uracil and thymine were found to act as the effectors that inactivate RutR regulator for shut-off of the de novo synthesis pathway of pyrimidines and instead the salvage pathway operates to use free pyrimidines for the synthesis of pyrimidine nucleotides.
He covers metabolism overall and its context; enzymes and coenzymes; the transport of small molecules; glycolysis and fermentation; respiration; non-glycolytic routes; amino acids, pyrimidines, and purines; carbohydrates, cofactors, and inorganic constituents; lipids; catabolism; and stress.
Folates are single carbon donors for the synthesis of purines, pyrimidines, and methionine and hence critical for DNA synthesis and cellular function.