Recent evidence of the existence of RNA polymerase
II (Pol II) pausing control in the bra locus in differentiating mammalian cells prompts the question of whether this mechanism is involved in the coordination of Bra expression.
PM1183 is an investigational drug from the class of inhibitors of the enzyme RNA polymerase
II, which is crucially involved in transcription[sup.
Different gene expression systems based on the xylose controlled promoter P(xylA) and various phage RNA polymerase
driven systems (for instance, T7) enable B.
In the internal genes of SH/JS01, we observed some human-like and mammalian-adapting signatures, including 89V in polymerase basic subunit (PB)2, 368V in PB1, 356R in the RNA polymerase
acidic subunit, 42S in nonstructural gene 1, and 30D and 215A in matrix gene 1; however, some hallmark changes involved in mammalian adaptation still showed avian signatures, including 627E and 701D in PB2 and 100 V and 409S in the RNA polymerase
acidic subunit (Table 2).
The virus relies on an enzyme called RNA polymerase
to infect and spread in a host.
Marikki Laiho and her colleagues say their work focused on the ability of a chemical dubbed BMH-21 to sabotage the transcription pathway RNA Polymerase
pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicate.
Escherichia coli RNA polymerase
activity observed using atomic force microscopy.
The 5' section contains an RNA transcriptional promoter sequence (usually, and as labeled here, a promoter as recognized by the commercially available purified RNA polymerase
from bacteriophage T7).
Similarly, in biologics, a transcriptor controls the flow of a specific protein, RNA polymerase
, as it travels along a strand of DNA.
First, they help unite RNA polymerase
with general transcription factors, molecules that make possible the reading of any piece of DNA.
NASDAQ: BCRX) today announced favorable preclinical results for BCX5191, a novel adenine nucleoside analog targeting viral RNA polymerase
for the potential treatment of hepatitis C.
Molecular characterization of human enteroviruses in clinical samples: comparison between VP2, VP1, and RNA polymerase
regions using RT nested PCR assays and direct sequencing of products.