RNAi


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RNAi

abbr.
RNA interference
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Rosetta Lung Cancer Test 111 Rosetta Kidney Cancer Test 111 Rosetta Mesothelioma Test 111 FIGURE 8 ROSETTA GENOMICS PIPELINE 112 MICRORNA PROFILING MARKET 112 TABLE 42 CANCER PROFILING, THROUGH 2015 ($ BILLIONS) 112 Microrna Profiling from Exiqon 113 Microrna Profiling from Asuragen 113 SUMMARY AND FUTURE PERSPECTIVES 113 TABLE 43 GLOBAL MICRORNA RESEARCH MARKET, THROUGH 2017 ($ MILLIONS) 114 TABLE 44 GLOBAL MICRORNA DIAGNOSTIC AND MICRORNA PROFILING MARKET, THROUGH 2018 ($ MILLIONS) 114 CHAPTER 8 RNAI IN AGRICULTURE 116 INTRODUCTION 116 RNAI-BASED BIOTECHNOLOGY SAFETY CONCERNS 116 RNAI APPLICATION IN CROPS 117 TABLE 45 NOVEL PLANT TRAITS ENGINEERED THROUGH RNAI 117 RNAI APPLICATION IN VIRUS AND PEST CONTROL 118 RNAI APPLICATION IN AQUACULTURE 119 SUMMARY AND FUTURE PERSPECTIVE 119
CHAPTER 9 COMPANY PROFILES 122 BIG PHARMA COMPANIES 122 PFIZER 122 ROCHE 122 LARGE AGRICULTURE COMPANIES 122 MONSANTO COMPANY 122 SYNGENTA AG 123 RNAI DRUG DEVELOPMENT COMPANIES 123 ALNYLAM PHARMACEUTICALS 123 ARROWHEAD RESEARCH CORPORATION 124 QUARK PHARMACEUTICALS INC.
LIST OF TABLES SUMMARY TABLE GLOBAL RNAI RESEARCH TOOL AND REAGENT, THERAPEUTIC, DIAGNOSTIC AND AGRICULTURE MARKET, THROUGH 2018 ($ MILLIONS) 7 TABLE 1 MICRORNA DATABASES 12 TABLE 2 COMPUTATIONAL TOOLS FOR MIRNA TARGET PREDICTION 13 TABLE 3 GLOBAL PHARMACEUTICAL MARKET, MARKET SHARES BY REGION AND TOP COMPANIES (%/$ MILLIONS/$ BILLIONS) 17 TABLE 4 COMPARISON OF U.
12 RNAI AS THERAPY 12 THE PROMISE OF RNAI 13 TABLE 1 VARIOUS TECHNOLOGIES FOR GENE SUPPRESSION 13 RNAI TECHNOLOGY 14 RNAI MECHANISM: HOW DOES IT WORK?
CHAPTER 5 RNAI-BASED THERAPEUTICS 71 RNAI-BASED THERAPEUTICS: THE EMERGING INDUSTRY LANDSCAPE 71 DELIVERING RNAI THERAPEUTICS 72 RNAi and Cancer Therapeutics 74 REGULATORY CONCERNS 74 RNAI IN CLINICAL TRIALS 75 Clinical Trials: RNAi 75 TABLE 15 THE GLOBAL RNA INTERFERENCE THERAPEUTIC PIPELINE 76 Other Candidates in Clinic 78 Terminated Programs 79 Other Programs 80 THERAPEUTIC RNAI DEVELOPMENTS 80 ALN-VSP02 80 Alnylam's ALN-RSV: Respiratory Syncytial Virus 82 ALN-RSV01 Treatment of Respiratory Syncytial Virus Infection in Lung Transplant Patients 83 TABLE 16 RECENT UPDATES: RNAi CLINICAL TRIALS 84 TABLE 17 CLINICAL TRIALS: RNAI-SYSTEMIC DELIVERY 85 CHALLENGES: RNAI-BASED THERAPIES 87