Apparently, large, reputable American drug manufacturers with the sort of experience and equipment to handle such a synthesis have stayed away from RU 486
. This presented smaller companies - - or new start-up companies - - with a considerable manufacturing challenge were they to decide to take on production of the abortifacient compound.
The only "place at the table" we want is for unborn children who otherwise would be starved to death (by use of the abortifacient RU 486
), or lethally evicted from their temporary home (death by conventional surgical abortions).
Mifepristone (RU 486
) is a steroid hormone with a chemical structure similar to natural hormone progesterone.
Mifepristone, a derivative of norethindrone, (RU 486
) is the initial vastly efficient progesterone receptor antagonist, binds to the progesterone receptor with an affinity equal to progesterone itself.
Delgado published the first peer-reviewed article in the medical literature on the reversal of mifepristone (RU 486
* AD-like symptoms were actually precipitated in healthy volunteers after treatment with the glucocorticoid receptor antagonist RU 486
First, mifepristone, also known as RU 486
, began U.S.
It's fairly straightforward to use the drug, formerly known as RU 486
, but the manufacturer's protocol is "out of date" because 4 years passed between the time the Food and Drug Administration granted approvable status to the drug and the time it was released for use, said Dr.
* BACKGROUND The United States Food and Drug Administration (FDA) has approved the use of mifepristone (RU 486
) in a protocol for early medical abortion. In that protocol, 600 [micro]g of mifepristone is followed by 400 [micro]g of oral misoprostol 48 hours later.
See RU 486
: The Import Ban and its Effects on Medical Research: Hearing Before the Subcomm.
This commentary explains the legal and regulatory status of RU 486
as used in combination with prostaglandin in France and addresses some of the legal questions that countries, including the United States, will have to face as they consider approval of this and other antiprogestin drugs for abortifacient purposes.
The physicians, feminists, and family-planning experts I interviewed then predicted that, given the political climate surrounding abortion, it could be 10 years before RU 486
, or mifepristone, would be approved for use by American women.