The patent includes claims that cover compositions of the immunologically active enantiomer of the cationic lipid R-1,2-dioleoyl-3-trimethyl-ammonium-propane or its racemic mixture
with Granulocyte-macrophage colony-stimulating factor to reduce the population of myeloid derived suppressor cells within the tumor microenvironment.
The process developed Takasago International Corporation produces pure menthol (-) enantiomer while the Haarmann-Reimer process produces a racemic mixture
of menthol enantiomers that can be separated by chiral resolution.
Clenbuterol is a racemic mixture
of two enantiomers banned in sport since 1992.
A) [theta]-cypermethrin: (4) enriched in 1R-cis-[alpha]S; B) [alpha]-cypermethrin: (3, 4) enriched in 1S-cis-[alpha]S + 1R-cis-[alpha]R; C) [beta]-cypermethrin: (3, 4, 7, 8) enriched in 1R-cis-[alpha]S + 1S-cis-[alpha]R and 1R-trans-[alpha]S + 1S-trans-[alpha]R; D) racemic mixture
of cypermethrin: (1,2, 5, 6) 1R-cis-[alpha]R + 1S-cis-[alpha]S and 1 S-trans-[alpha]R + 1R-trans-[alpha]S (other peaks described above).
Bupivacaine is used as a racemic mixture
of equimolar amounts of R (+) Dextrobupivacaine and S (-) Levobupivacaine.
Chemical method produces racemic mixture
of both D (-) and L (+) lactic acid while fermentation method produces only one optically pure form of D (-) or L (+) lactic acid, respectively .
In nature, cathinone exists as a racemic mixture
that contains one chiral center which means that it has two enantiomers and commonly one of them will have greater psychological effect in human biological system than the other enantiomer .
Commercially, ketamine is available as a racemic mixture
and, more recently, as a formulation containing only the S(+)-isomer.
(41) It is also sometimes the case that while, say, the negative enantiomer is responsible for the therapeutic benefits of the drug, the positive enantiomer is actually inhibiting those benefits, so removing the positive enantiomer from the racemic mixture
will have a more than two-fold increase in the therapeutic effects of the drug.
Research regarding the biological effects of gossypol both in vitro and in vivo showed that the (--)-enantiomer is more potent than the (+)-enantiomer or the racemic mixture
Warfarin is a racemic mixture
and it is metabolized via cytochrome enzymes in the liver.
TNX-201 is also likely to possess favourable safety and tolerability relative to both the other isomer and to the racemic mixture
, and potentially have an improved clinical profile as compared to the unapproved racemic IMH for headache indications.