clinical trial

(redirected from Randomized controlled trial)
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Noun1.clinical trial - a rigorously controlled test of a new drug or a new invasive medical device on human subjects; in the United States it is conducted under the direction of the FDA before being made available for general clinical use
trial, run, test - the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial"
phase I, phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained
phase II, phase II clinical trial - a clinical trial on more persons than in phase I; intended to evaluate the efficacy of a treatment for the condition it is intended to treat; possible side effects are monitored
phase III, phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
phase IV, phase IV clinical trial - sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug may be tried on slightly different patient populations than those studied in earlier trials
References in periodicals archive ?
Understanding the gap between efficacy in randomized controlled trials and effectiveness in real-world use of GLP-1 RA and DPP-4 therapies in patients with type 2 diabetes.
The authors conducted a randomized controlled trial attempting to demonstrate the therapeutic relevance of OMT in the pediatric asthma population.
Soon Randomized controlled trial became the standard of medical research and placebo became its integral component.
Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA.
Total extraperitoneal inguinal hernia repair compared with Lichtenstein (the level-trial): a randomized controlled trial. Ann Surg 2010; 251:819-24.
Gao et al., "Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial," BMC Medicine, 2015, 13:162, DOI: 10.1186/s12916-015-0399-z
The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials. J Bone Miner Res.
Assessment of adherence to the CONSORT statement for quality of reports on randomized controlled trial abstracts from four high-impact general medical journals.
Researchers conducted a randomized controlled trial to determine whether preapplication of lidocaine-epinephrine-tetracaine would decrease pain in children undergoing repair of minor cuts with tissue adhesive.
Data Source: First randomized controlled trial comparing robotic-assisted and laparoscopic hysterectomy in 53 women.
In a randomized controlled trial, 439 women were assigned to a dietary weight loss group designed for 10 percent weight loss, or an exercise group scheduled for 45 minutes/day, five days/week of moderate-to-vigorous activity, an exercise dietary weight loss group, or a control group.
Effect of screening on ovarian cancer mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA, 305, 2295-2303.

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