ras gene


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Related to ras gene: p53, RB gene, Proto oncogene

ras gene

 (răs)
n.
Any of several oncogenes that code for Ras proteins.
References in periodicals archive ?
The Phase Ib exploratory, multi-site, open-label, non-randomised trial will enrol around 20 patients with locally recurrent rectal cancer, where specific poor-prognosis mutations in the RAS gene have been confirmed.
Thus, immunohistochemistry with SP174 antibody is a useful tool in the screening of colorectal carcinomas for RAS Q61R mutant proteins; however, molecular genetic confirmation is necessary to determine which RAS gene is mutated.
Moreover, the RAS gene mutation was not a predictor for disease-specific survival [22].
Of all the members of the intracellular signalling pathway, only members of the ras gene family encode for the related protein P (21) localized to the cytoplasmic side of the cellular membrane.
Mutations in the RaS gene family are found in 30% of all human cancers and are also commonly seen in OSCC.
It is thought that adenomas incur a mutation of the ras gene leading to their evolution into "intermediate" adenomas.
Mutations that make one of these, the Ras gene, hyperactive prompt cells to proliferate wildly.
Applying techniques of molecular biology the researchers sequence each patient's abnormal RAS gene to identify the specific mutation.
Of note mutations in the Ras gene family (including H- K- and N-Ras) have been implicated in 30% of all human cancers.
The RAS gene family acts as a molecular on/off switch; when it is turned on (or mutated) it recruits and activates proteins necessary for the propagation of the receptor's signal, such as c-Raf and lipid kinase phosphoinositide-3 kinase.
Carlsbad, CA) has patented compositions and methods for the modulation of expression of the human ras gene in both the normal and activated forms.
To explore this possibility, the researchers first applied one of the chemicals to human cancer cells that carried a mutant Ras gene.