Redox-active metals, such as iron, copper and chromium, undergo redox cycling
whereas redox-inactive metals, such as lead, cadmium, mercury and others deplete cells' major antioxidants, particularly thiol-containing antioxidants and enzymes.
The water-soluble copper porphyrinate, copper (II) porphyrinate (CuTPPs = [5,10,15,20- tetrakis(N-methylpyridyl-4)porhinato]copper(II) tetratosylate)), was previously examined by UV-Vis and electron paramagnetic (EPR) spectroscopy for its ability to engage in a number of reactions involving either axial ligation to the copper or possible redox cycling
, with ligands and potential redox partners such as nitrite, imidazole, dithionite, 2,2'-azino-bis(3- ethylbenzthiazoline-6-sulphonic acid) (ABTS) and guaiacol .
It has been found that benzyl homologue caused pulmonary toxicity which was at least five times as toxic to rats as paraquat and they have more pronounced ability to trigger redox cycling
reaction than paraquat .
Zhu, "Hydroxyl radical generation mechanism during the redox cycling
process of 1,4-naphthoquinone," Environmental Science & Technology, vol.
The topics include the molecular regulation of selenocysteine incorporation into proteins in eukaryotes, a historical view of redox cycling
and the toxicity of selenium compounds, forms of selenium in cancer prevention, multifaceted and intriguing effects of selenium and selenoproteins on glucose metabolism and diabetes, and the functionality and disease risk of genetic polymorphisms in selenoprotein genes.
Heavy metal pollutants found in the soil can cause their deleterious effects by one of four ways [3,4]: 1) These heavy metals can undergo redox cycling
and in the process lead to oxyradical production which then causes oxidative stress in soil organisms, 2) they can bind directly to sulfhydryl groups of proteins and lead to protein inactivation and denaturation, 3) they can bind to intracellular glutathione (GSH) or antioxidant enzymes (e.
2011) and b) ROS generation through redox cycling
(Rodriguez et al.