Reed-Sternberg cell

Also found in: Medical, Acronyms, Encyclopedia, Wikipedia.
Related to Reed-Sternberg cell: Hodgkin's lymphoma

Reed-Stern·berg cell

A large, abnormal, binucleated or multinucleated B cell that is characteristic of Hodgkin lymphoma.

[After Dorothy M. Reed (1874-1964), American pathologist, and Carl Sternberg (1872-1935), Austrian pathologist.]
References in periodicals archive ?
Hodgkin lymphoma is marked by the presence of an abnormal lymphocyte called the Reed-Sternberg cell (or B lymphocyte).
The fine needle aspiration cytology showed medium to large malignant lymphocytes having finely dispersed chromatin with look-alike of Reed-Sternberg cell, which was suggestive of malignant lymphoma.
Chronic lymphocytic leukemia with coexistent Hodgkin's disease: implications for the origin of the Reed-Sternberg cell.
Both EBV DNA and EBV gene products (such as the EBVencoded small RNAs) are readily detectable in the pathognomonic cell of Hodgkin disease, the Reed-Sternberg cell in a significant portion of the cases in the West (especially in lymphomas of the mixed cellularity subtype), and in almost all patients in countries where EBV infection in childhood is endemic (50-53).
In other disorders where the Reed-Sternberg cell is found, the other elements do not surround the cell.
Determination of the DNA content of the Reed-Sternberg cell of Hodgkin's disease by image analysis.
2-6] Given the unique morphology and immunophenotype of the Reed-Sternberg cell, which is so characteristic of Hodgkin disease, the nature of Hodgkin disease has until recently been a mystery.
Histiocytoid cells with large, vesicular nuclei and "inclusion-like" nucleoli that mimic Reed-Sternberg cells are characteristic of myxoinflammatory fibroblastic sarcoma and can be found in most tumors (hematoxylin-eosin, original magnification X600).
The diagnosis of Hodgkin Lymphoma in lung is based on the recognition of diagnostic Reed-Sternberg cells with reactive cellular infiltrate in the background.