Transit of material through the gastrointestinal tract relies on a balanced release of contractile neuromodulators orad of the food bolus and the release of relaxative
neuromodulators caudad of the bolus, thus propelling the food in a forward direction (proximal to distal).
Lei et al., "Relaxative
effect of core licorice aqueous extract on mouse isolated uterine horns," Pharmaceutical Biology, vol.
D3 has also been reported to have a vascular relaxative
effect in the endothelial cells of rat aortic rings, similar to the effect of estrogen (Intapad et al.
The endothelium-dependent relaxative effect by Ach was studied as an index of endothelial function.
Secondly, it was considered to increase the contractive factor because of decreasing the endothelial-dependent relaxative effect.
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Other studies have reported that tokishakuyakusan (TSS) has an inhibitory effect on platelet aggregation and a relaxative effect on vascular smooth muscle [10,11].
Polyphenols of Cinnamomi Cortex or cinnamaldehyde, included in KBG and HJG, have been reported to have an endothelium-dependent relaxative effect [30-33].