Serious, life-threatening, or fatal respiratory depression
Severe side effects included seizures (6%), hallucinations (5%), respiratory depression
(3%), and coma (2%).
The cause of death was given as respiratory depression
or breathing difficulties caused by opiod toxicity after high levels of heroin derivative free-morphine was found in his blood.
The Complaint alleges that Endo also knew the dangers of its opioid products, including increased risks of respiratory depression
and death in elderly patients, and failed to clearly disclose those risks while it specifically targeted patients in that age group.
One of Jain's patients, identified only as "M.E.B." in court records, died in 2009 of respiratory depression
after taking methadone Jain had prescribed.
Baby Ethan Muendo, whose death led to the closure of Shalom Community Hospital in Machakos County on Monday, died due to respiratory depression
, a preliminary autopsy investigation conducted at Montezuma Funeral Home has revealed.Pathologist Daniel Zuriel said the baby's brain was swollen, leading to the respiratory depression
since breathing is controlled by the brain.
The patches themselves do say 50 mcg/h, but if a patient who purchased the 12 mcg/h carton doesn't notice this and uses the 50 mcg/h patch, it could lead to "serious, life-threatening, or fatal respiratory depression
," according to the recall.
They tested the app on 94 drug users as they injected themselves; half of the users "experienced clinically important respiratory depression
," and two needed to be treated by clinic staff for overdose.
Adverse effects like sedation, pruritis, nausea, vomiting, respiratory depression
The inquest, held in Middlesbrough Town Hall, heard the medical cause of death was given as respiratory depression
, toxicity from the medication, and obesity.
Preclinical data presented last year at the Academic Drug Discovery Consortium revealed that its G-protein agonists lack the dangerous side effects of respiratory depression
and abuse potential associated with all currently marketed opioids.