Rh incompatibility


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Related to Rh incompatibility: Rh factor, Rhogam, Coombs test, ABO incompatibility
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Noun1.Rh incompatibility - incompatibility of Rh blood types; a transfusion of Rh-positive blood given to a Rh-negative person (or vice versa) can result in hemolysis and anemia
incompatibility - (immunology) the degree to which the body's immune system will try to reject foreign material (as transfused blood or transplanted tissue)
References in periodicals archive ?
When the cases were assessed for jaundice etiologies, the number of cases with hemolysis due to ABO or Rh incompatibility, excessive weight loss (loss of [greater than or equal to]10% of birth weight) and prematurity were 17 (15%), 20 (18%) and 19 (17%), respectively.
Mean and standard deviation of serum calcium before phototherapy in RH incompatibility group were 9.5231 and 0.8318 respectively.
The pathophysiology of isoimmunization in minor blood group incompatibility in the fetus and newborn is similar to the pathophysiology of Rh incompatibility. The initial maternal antibodies produced as a response to antigenic stimulus are immunoglobulin (Ig)-M antibodies, but they have no importance in the pathogenesis of hemolytic disease of the newborn because they cannot cross the placenta.
A total of 59 patients had babies with neonatal hyperbilirubinemia after exclusion of Rh incompatibility. We detected that the presence of in vitro pregnancy, maternal health problems or poor obstetric history had no effect on the risk for neonatal hyperbilirubinemia.
Prenatal factors included Rh incompatibility (n=1), maternal inflammatory disease in pregnancy (n=1), and maternal jaundice in pregnancy (n=1).
Neonates with congenital anomalies and syndromes, Rh incompatibility and G6PD deficiency were excluded.
Rh incompatibility was present in 20.9% newborns in group A and 11.11% newborns in group B.
9.4% had Rh incompatibility and cephalohematoma was present in 4.6%.
(1-6) ABO Rh incompatibility results in severe hemolytic disease of newborn in India, Sri Lanka and Bangladesh and it often requires multiple exchange transfusions.
This approach has been used to determine whether a fetus is Rh negative or positive in the context of the risk for Rh incompatibility. Similarly, a fetus at risk of inheriting a dominant mutation (e.g., polyposis coli) from the father can be tested for the presence of the mutation.
If the antigens on the mother's red blood cells differ from the antigens on the unborn fetus red blood cells you could have either an ABO blood group incompatibility or a Rh incompatibility. We will look at Rh incompatibility for our example.