In this study, the number of subjects was small (5 women completed the metformin arm, and 9 women the rosiglitazone
arm), and the groups differed greatly at baseline, with the metformin group being heavier and the rosiglitazone
group being more hirsute and having higher serum testosterone and insulin levels.
The data on rosiglitazone
(GlaxoSmithKline's Avandia) were presented in a poster by Guissou Dabiri, a clinical pharmacologist with the company in King of Prussia, Pa., and her associates.
(brand name: Avandia) is a drug used to treat diabetes.
* [Abstract LB 13] Rosiglitazone
, a diabetes drug which increases subcutaneous fat in patients with type 2 diabetes, did not significantly increase subcutaneous fat in a 24-week trial with 15 HIV patients with lipoatrophy who were on the drug, compared to 15 controls.
Other names for this medicine Generic name Brand name pioglitazone Actos (py-oh-GLIT-uh-zone) (ACT-ose) rosiglitazone
Avandia (rose-ee-GLIT-uh-zone) (uh-VAN-dee-uh)
The latest approved product, developed to improve target cell response to insulin, is Avandia (rosiglitazone
maleate, SmithKline Beecham).
There are two types of PPAR-[gamma] ligands: natural ligands such as fatty acids and eicosanoid derivatives  and synthetic ligands such as thiazolidinediones ketones (thiazolidinedione, TZD), of which rosiglitazone
) and pioglitazone (pioglitazone) are used in clinical medicine as a treatment for type 2 diabetes .
The article describes the Phase 1 study, in which the pharmacokinetic parameters of rosiglitazone
, a thiazolidinedione agent commonly used for type 2 diabetes, were measured in the absence and presence of SCY-078 dosed to therapeutically relevant levels in healthy adult subjects.
We also examined the effect of adipogenic agent rosiglitazone
on the regulation of GPR43 transcription in brown adipocytes to understand more about the possible underlying mechanism.
is one of the currently used TZDs/PPAR-[gamma] agonists in the treatment of type 2 diabetes.
Regarding the PPAR g agonists, the most important is Rosiglitazone
is a drug belonging to the family of thiazolidinediones.
(10mg/kg, i.p., Sigma-Aldrich, CA, USA) or T0070907 (1.5 mg/kg, i.p., Selleck Chemicals, Houston, TX, USA) or sterile normal saline was administered 60 minutes before surgery.