com/cell/fulltext/S0092-8674(18)30057-6) open-access paper that appeared Thursday in the journal Cell, said the researchers tried a number of different ways to get SCNT
to work with monkeys, and failed a number of times before finally succeeding.
We demonstrated that targeted cells could possibly be used as nuclear donors in SCNT
and are capable of directing development to at least 90d of pregnancy by second round SCNT
Professor Sinclair added: "Despite technological advances in recent years, efficiency of SCNT
remains low but there are several groups across the world working on this problem at present and there is reason to be optimistic that there will be significant improvements in future.
is currently being performed in several laboratories worldwide for the purpose of creating human stem cells.
One attraction of SCNT
has always been that the genetic identity of the new pluripotent cell would be the same as the patient's, since the transplanted nucleus carries the patient's DNA," said cardiothoracic surgeon Sonja Schrepfer.
The problem of abnormally large offspring was first described for calves born from blastomere NT procedures (6, 7) but was subsequently shown to occur in embryos produced by IVF (8, 9) and SCNT
(10, 11, 12, 13) procedures.
The article quoted DeGette as saying, "I hope the NIH will allow SCNT
[human cloning] to move forward with federal funding.
Having learnt some lessons from SCNT
(cloning), we need to be very cautious in generating stem cells by directed differentiation (IPS) or de-differentiation for cell therapy to treat diseases.
Leaving aside the question of whether body parts and tissues should be bought and sold for any purpose, it's important to note that eggs used for reproduction will result in a baby at least some of the time, while benefits from SCNT
research are unknown.
The General Assembly of the United Nations failed to reach agreement on a treaty regarding somatic cell nuclear transfer, also known as SCNT
(Caulfield and von Tigerstrom 2005).
294), while SCNT
(following McHugh) results in "an embryo-like entity that can form tissue but not organize a fetus .
The resulting restrictive statutory provisions that ban SCNT
ultimately arose from a convergence of rhetoric on dignity and the moral status of the embryo, and the resultant promotion of adult stem cell research.