describes the ability of HeLa cells to upregulate an amino acid transporter, solute carrier family 1 member 5 (SLC1A5
), which imports tryptophan, whereas co-cultured T-cells were unable to do so, thus disabling their cytotoxic functioning.
Expressions of amino acid transport-related genes, such as SLC1A1, SLC1A5
, SLC7A1, SLC7A7, and SLC15A1, were significantly increased by spermine supplementation (Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d; p<0.05).
Hou, "PPAR]delta] promotes tumor progression via activation of Glut1 and SLC1A5
transcription," Carcinogenesis, vol.
Glutamine is the most abundant amino acid in the plasma and is internalized in macrophages via the membrane transporter Slc1a5
(solute carrier family 1 member 5) (Figure 2(b)).
Fan, "ASCT2 (SLC1A5
) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis," Cancer Letters, vol.
Neutral AA transporters, solute carrier family 1, member 5 (SLC1a5
) and family 16, member 10 (SLC16a10), are responsible for threonine, serine, alanine, cysteine, glutamine and phenylalanine, tyrosine, and tryptophan transporting, respectively.