12,29) A recent review of augmentation of MAOIs with second-generation antipsychotics found multiple positive reports for most agents, including aripiprazole, with the sole exception of ziprasidone, a moderate SNRI
for which cases of SS have been reported.
In another study it was seen that adding L-Methylfolate to selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs
) when starting pharmacotherapy leads to greater reduction of depressive symptoms in a shorter time compared with SSRI or SNRI
To treat panic disorder with medication, start with a very low dose of an SSRI or SNRI
, such as paroxetine 10 mg/d.
More than 80% of the study group as a whole had achieved the MTD for their SSRI or SNRI
by 3 months after diagnosis of MDD.
It seems that SSRI and SNRI
could be a reasonable alternative treatment for menopausal vasomotor symptoms in women who cannot take the menopausal hormone therapy or are concerned about the long-term effects of estrogen, but those medications are not an optimal choice for the patients with no contraindication for conventional MHT.
An overview of the different characteristics of SNRI
portal was presented during the meeting.
Il est important de mentionner que l'ANPR et l'API pilotent l'enrichissement du portail SNRI
Regarding the risk of developing sexual dysfunction, antidepressants can be divided into a high risk category (SSRI, SNRI
, TCA and IMAO), respectively, a low risk category (agomelatine, bupropion, reboxatina).
Abbreviations: BPH = benign prostatic hypertrophy, CPG = clinical practice guideline, DOD = Department of Defense, FY = fiscal year, ICD-9 = International Classification of Diseases 9th Revision, PTSD = posttraumatic stress disorder, SSRI/ SNRI
= serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor, VA = Department of Veterans Affairs, VHA = Veterans Health Administration.
Si and Wang  suggest that the lower side effect profile of SSRIs and SNRIs
may result in less problems when combining multiple SSRIs or SNRIs
than when combining SSRIs with MAOIs or TCAs; but the safety of some these potential SSRI and SNRI
combinations has not been formally assessed, so clinicians need to be correspondingly cautious.
The benzodiazepines are best reserved for short-term use (2-4 weeks) in the early phase of treatment of GAD with an SSRI or SNRI
to provide some symptomatic relief until the antidepressant has begun to work, to treat insomnia if it is a predominant symptom, and to protect against occasional early worsening of anxiety seen with the initiation of therapy.
12] A number of recent literature reviews compare the efficacy, safety, and tolerability of the currently available second-generation antidepressants, such as the SNRI