SV40


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SV40

 (ĕs′vē-fôr′tē)
n.
A polyomavirus found in humans and other mammals that causes tumors in certain species, such as hamsters and rats, and various diseases in immunocompromised monkeys. It has been widely researched as a model of viral replication and gene expression and a possible cause of certain cancers in humans.

[s(imian) v(irus) 40.]
References in periodicals archive ?
BK virus, one of the polyomaviruses along with CMV, JCV, and SV40, is found in serum of up to 90% of healthy adults, despite being asymptomatic.
cNLSs are divided into two types, a monopartite type such as the NLS of the SV40 large T antigen (PKKKRKV) consisting of one cluster of basic amino acids, and a bipartite type such as that of nucleoplasmin (KRPAATKKAGQAKKKK) composed of two clusters of basic amino acids separated by linker amino acids.
It was essential to compare the cracking risk of low-heat concrete with that of SV40 concrete which is commonly used in Norway.
Previously, our group succeeded to establish immortalized PDL cell lines using SV40 large T-antigen and human telomerase reverse transcriptase [59].
As all SVGA cells, being SV40 transformed, permanently express SV40 LT, we used expression of the JCPyV major capsid protein VP1 as a marker for JCPyV infection of SVG-A cells.
Pascual-Montano et al., 2001 [48], also used ML classification and NN (SOM) to look at the variability of negative stain images of the G40P helicase of Bacillus subtilis bacteriophage SPP1 and cryoelectron images of the Simian Polyomavirus SV40 large T-antigen.
Gredler et al., "Transcription factor late SV40 factor (LSF) functions as an oncogene in hepatocellular carcinoma," Proceedings of the National Academy of Sciences of the United States of America, vol.
BK virus (BKPyV) JC virus (JCPyV) and simian 40 (SV40) are members of the Polyomaviridae family [1].
For example, Angiotensin II (Ang II), the primary hormone of the RAS, promotes the proliferation of mouse fibroblast 3T3 cells (but not SV40 transformed 3T3 cells in culture) [3], DNA synthesis and proliferation of adrenal cortical cells in culture [4], and the hypertrophic and hyperplastic growth of vascular smooth muscle cells [5].
In the class, a graduate student tells us of new work from California: taking the tumor virus of my laboratory, SV40; excising the T-antigen gene that encodes the virus's tumorigenic activity, recombining its DNA with the DNA of E.
The simian virus 40 (SV40), for example, is a polyoma virus found in the monkey kidneys used to make polio and smallpox vaccines.