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Related to scleroderma: Lupus, Sjogren's syndrome


A pathological thickening and hardening of the skin.


(ˌsklɪərəʊˈdɜːmə) ,




(Pathology) a chronic progressive disease most common among women, characterized by a local or diffuse thickening and hardening of the skin
[C19: from New Latin sclerōdermus, from Greek, from sklēros hard + derma skin]


(ˌsklɪər əˈdɜr mə, ˌsklɛr-)

a disease in which connective tissued becomes hardened and rigid.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.scleroderma - an autoimmune disease that affects the blood vessels and connective tissuescleroderma - an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
morphea - localized scleroderma
2.Scleroderma - genus of poisonous fungi having hard-skinned fruiting bodies: false truffles
fungus genus - includes lichen genera
family Sclerodermataceae, Sclerodermataceae - a family of fungi or order Sclerodermatales with a single-layered peridium; includes earthballs
earthball, hard-skinned puffball, puffball, false truffle - any of various fungi of the genus Scleroderma having hard-skinned subterranean fruiting bodies resembling truffles
Scleroderma aurantium, Scleroderma citrinum - an earthball fungus that is a dingy brownish yellow and a dark purplish interior; the peridium is covered with a pattern of small warts
Scleroderma flavidium, star earthball - an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel
Scleroderma bovista, smooth earthball - an earthball with a peridium that is firm dry and smooth when young but developing cracks when mature; pale orange-yellow when young and reddish brown at maturity


n. escleroderma, esclerodermia, induración y casi total atrofia de la epidermis.


n esclerodermia, esclerosis sistémica progresiva; localized — esclerodermia localizada
References in periodicals archive ?
The presence of characteristic clinical features led to the diagnosis of scleroderma.
Scleroderma is a chronic, autoimmune disease that can cause hardening and thickening of the skin and attack the heart, lungs, kidneys and gastrointestinal tract.
Scleroderma is a multisystem disease that starts with the inflammation and atrophy of small blood vessels and leads to fibrosis of the skin and visceral organs.
A small number of people who have Raynaud''s can also develop scleroderma, a disease which affects the connective tissue.
There is evidence that solvent exposure causes scleroderma (1,2), an autoimmune connective tissue disease with RP being a common symptom.
However, it can also be an early symptom of scleroderma.
Scleroderma (progressive systemic sclerosis) is a multisystem disease of unknown etiology that involves the esophagus in 75 to 90% of cases.
The heart is something we often forget in scleroderma.
A 33-year-old right-handed man with a history of linear scleroderma and classic migraine headache presented with unilateral right-sided paresthesias involving the upper and lower extremities and the face.
To reappraise the hypothetic diagnosis of scleroderma.
Scleroderma is arare disease that causes tightening of the skin and stiff joints and can lead to several health complications
Patients with a certain type of scleroderma may get cancer and scleroderma simultaneously, suggesting that in some diseases, autoimmunity and cancer may be linked, researchers said.