5 to 2 hours after taken: dyskinesia (chorea), dystonia, agitation, ortho hypotension, N&V, confusion, vivid dreams, hallucinations, psychosis Avoid MAOI's except for selegiline
Lodosyn (carbidopamine) 25 mg tabs, 1:10 ratio w/ levodopamine, max 200mg/d Use--decrease N&V, allow B6 to be given decrease levodopamine dose prevents peripheral breakdown of levodopamine SE--does not decrease CNS SE of L-dopamine Selective MAOI, no diet restriction needed Eldypryl, Deprenyl (selegiline
) 5 mg tabs, 5mg po bid, no benefit with increase.
Being first with ticlopidine allowed Apotex access to customers in order to present other recent product approvals, including diltiazem, pentoxifylline and selegiline
may help patients who have trouble taking oral medications, including antidepressants.
tapered to discontinuation, and orally disintegrating selegiline
A systematic review of 4 RCTs (662 patients) found that antidepressants--fluoxetine, paroxetine, imipramine, tranylcypromine, and selegiline
(1-deprenyl)--significantly increased treatment response for bipolar type I or II disease at 4 to 10 weeks.
For drug intervention, a monoamine oxidase inhibitor called selegiline
(Anapryl) has been approved for CDS in dogs in the united States.
WASHINGTON -- An orally disintegrating formulation of selegiline
appears to be a safe and effective adjunct for patients with Parkinson's disease who are experiencing a deterioration of levodopa response, according to data presented in a poster at the World Parkinson Congress.
The lowest of the three doses approved, the patch that delivers 6 mg of selegiline
over 24 hours, does not require dietary tyramine restrictions, making this the first MAO inhibitor approved for treating depression without such a restriction.
Today Novopharm USA markets drugs in 20 groups, including such popular products as naproxen, naproxen sodium, loperaminde, flurbiprofen, mexiletine, annoxicillin, nifedipine, glyburide, cephalexin, piroxicam, diclofenac and selegiline
is the only MAOI available as a transdermal patch.
Apomorphine, cabergoline, and selegiline
"may be considered" (C).