selegiline


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se·leg·i·line

 (sə-lĕj′ə-lēn′)
n.
A selective monoamine oxidase inhibitor, C13H17N, used transdermally as an antidepressant and in its hydrochloride form in conjunction with levodopa and carbidopa to treat patients with Parkinson's disease.

[Probably sele(ctive) (from its being a selective monoamine oxidase inhibitor) + alteration of (par)gyline, a closely related drug (ultimately from Latin arg(entum), silver; see arg- in Indo-European roots from the fact that one of the constituents of pargyline was discovered in a precipitate containing silver + -yl + -ine).]

selegiline

(səˈlɛɡɪˌliːn)
n
(Medicine) a drug used in treating Parkinson's disease, depression and dementia
Translations

selegiline

n selegilina
References in periodicals archive ?
5 to 2 hours after taken: dyskinesia (chorea), dystonia, agitation, ortho hypotension, N&V, confusion, vivid dreams, hallucinations, psychosis Avoid MAOI's except for selegiline Lodosyn (carbidopamine) 25 mg tabs, 1:10 ratio w/ levodopamine, max 200mg/d Use--decrease N&V, allow B6 to be given decrease levodopamine dose prevents peripheral breakdown of levodopamine SE--does not decrease CNS SE of L-dopamine Selective MAOI, no diet restriction needed Eldypryl, Deprenyl (selegiline) 5 mg tabs, 5mg po bid, no benefit with increase.
Being first with ticlopidine allowed Apotex access to customers in order to present other recent product approvals, including diltiazem, pentoxifylline and selegiline capsules.
Transdermal selegiline may help patients who have trouble taking oral medications, including antidepressants.
tapered to discontinuation, and orally disintegrating selegiline was continued.
A systematic review of 4 RCTs (662 patients) found that antidepressants--fluoxetine, paroxetine, imipramine, tranylcypromine, and selegiline (1-deprenyl)--significantly increased treatment response for bipolar type I or II disease at 4 to 10 weeks.
For drug intervention, a monoamine oxidase inhibitor called selegiline (Anapryl) has been approved for CDS in dogs in the united States.
WASHINGTON -- An orally disintegrating formulation of selegiline appears to be a safe and effective adjunct for patients with Parkinson's disease who are experiencing a deterioration of levodopa response, according to data presented in a poster at the World Parkinson Congress.
The lowest of the three doses approved, the patch that delivers 6 mg of selegiline over 24 hours, does not require dietary tyramine restrictions, making this the first MAO inhibitor approved for treating depression without such a restriction.
Today Novopharm USA markets drugs in 20 groups, including such popular products as naproxen, naproxen sodium, loperaminde, flurbiprofen, mexiletine, annoxicillin, nifedipine, glyburide, cephalexin, piroxicam, diclofenac and selegiline and cimetidine.