Thirty-five patients had seminomatous
testicular tumors, whereas 38 patients had nonseminomatous testicular tumors.
(26) demonstrated that both K-RAS and N-RAS mutations coexist in 2 patients with seminomatous
tumors and another with nonseminomatous tumors.
Management of seminomatous
testicular cancer: A binational prospective population-based study from the Swedish Norwegian testicular cancer study group.
concluded that although hCG in patients with NSGCTs was mainly hyperglycosylated, the determination of hCG-h in serum did not provide clinical information additional to that obtained by conventional hCG assays that also recognize hCG-h; by contrast the separate measurement of hCG[beta] enhanced the detection of relapse and improved the diagnosis of seminomatous
Interestingly, it is uncertain whether TTE poses an independent risk factor for testicular malignancy but has been linked to seminomatous
, nonseminomatous germ cell tumours, and teratomas in published literature [19, 20].
Graziana et al., "Dendritic cell infiltration in a patient with seminomatous
germ cell tumor of the testis: is there a relationship with infertility and tumor stage?," Journal of Urology, vol.
However, significant elevation in serum AFP level virtually excludes a diagnosis of pure seminoma, even though microscopic evaluation may show only the seminomatous
Ultrasound is usually the first step to diagnosis; however, seminomatous
and nonseminomatous testicular masses can easily mimic the STI appearance on ultrasound.
AFP is usually not elevated in pure seminomatous
Additionally, AFP can be useful in differentiating seminomatous
germ cell tumors from nonseminomatous germ cell tumors in that the former does not produce AFP.
Lesions may be divided into seminomatous
and nonseminomatous types.
While most cases of testicular cancer require orchidectomy, or the removal of a testicle, one British study of 33 men with advanced germ cell tumors found that chemotherapy found that chemotherapy alone was enough to eradicate the cancer in 64 percent of the patients that had a certain kind of cancer called "pure seminomatous
," characterized by tumors with large round cells.