(redirected from Semisynthesis)
Also found in: Thesaurus, Medical, Wikipedia.


 (sĕm′ē-sĭn-thĕt′ĭk, sĕm′ī-)
1. Prepared by chemical synthesis from natural materials: a semisynthetic antibiotic.
2. Consisting of a mixture of natural and synthetic substances: a semisynthetic culture medium.


(Textiles) textiles partly synthetic and partly natural in composition


(ˌsɛm i sɪnˈθɛt ɪk, ˌsɛm aɪ-)

derived synthetically from one or more substances of natural origin.
sem`i•syn•thet′i•cal•ly, adv.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.semisynthetic - not of natural originsemisynthetic - not of natural origin; prepared or made artificially; "man-made fibers"; "synthetic leather"
chemical science, chemistry - the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions
artificial, unreal - contrived by art rather than nature; "artificial flowers"; "artificial flavoring"; "an artificial diamond"; "artificial fibers"; "artificial sweeteners"
References in periodicals archive ?
Meng, Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins, J Ginseng Res., 41, 373 (2017).
Optically pure amino acids have been widely used as intermediates for semisynthesis of antibiotics, active peptides, hormones, antifungal agents, pesticides, and sweeteners.
Thadhani, Semisynthesis and Bioactivities of Lichen Metabolites, Scholars' Press, 2013.
Blagg, "Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structureactivity relationships," Journal of Medicinal Chemistry, vol.
Thus, for instance, vinorelbine, a chemotherapeutic obtained by semisynthesis from alkaloids extracted from the rosy periwinkle (Catharanthus roseus), has been loaded into a cholesterol-polyethylene glycol (cho-PEG) coated liposome with the purpose of increasing circulating half-life and reducing severe side effects of this agent [94].
In fact, several efforts have been developed towards the effective semisynthesis of this compound (Huang et al., 2007) and to the study of its in vivo metabolic pathways, identifying the major metabolites in rat urine and plasma after oral administration (Lei et al., 2011).