They would have stuck with Flonase and Serevent
, even if using those drugs separately was mildly less convenient.
Currently, salmeterol (Serevent
) is only available in a dry powder inhalation formula, at 50 micrograms per inhalation.
Diskus) and formoterol (Foradil Aerolizer) are two bronchodilators in a class of medications known as longacting beta agonists (LABAs).
Nationwide Surveillance study and the U.S.
In his testimony before Congress, Graham identified six drugs that he said were approved by the FDA over grave safety concerns: Vioxx; Crestor (a cholesterol lowering drug linked to kidney failure and myopathy, including cardiomyopathy); Meridia (a weight loss drug linked to increased risk of heart attack and stroke); Bextra (a pain killer linked to increased risk of heart attack and stroke); Accutane (an acne drug linked to birth defects if used by pregnant women); and Serevent
(an asthma drug linked to increased risk of death from asthma).
Single-agent LABAs, such as Serevent
and Foradil, should never be used in asthma patients of any age without concurrent use of an asthma controller medication such as an inhaled corticosteroid.
The specific (LABA) drugs that should not be taken alone are Serevent
, Foradil, Advair, and Symbicort.
Those on monotherapy with tiotropium (Spiriva) had significantly lower rates of disease-related hospital admissions during 12 months of follow-up than those on salmeterol (Serevent
), formoterol fumarate (Foradil), salmeterol/fluticasone propionate (Advair), or combination therapy with two or more LABDs, said Dr.
The LABA products approved in the United States are Serevent
(salmeterol) and Foradil (formoterol), which contain the LABA alone, and Advair (salmeterol plus fluticasone) and Symbicort (formoterol plus budesonide), which contain the LABA and an inhaled corticosteroid.
The restrictions also affect two lesser-used medicines, Glaxo's Serevent
and Novartis AG's Foradil.
For the long-acting beta-2 agonists however, detrimental effects have not been shown to be related to the presence of an Arg/Arg polymorphism of the beta-2 adrenergic receptor in studies of both formoterol and Serevent
, used in combination with a steroid.
The regimen prescribed inhaling one dose of Serevent
every morning and another dose every evening.