The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone
), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
The other medication in this class, Serzone
(nefazodone), increases REM with subjective reports of vivid dreams or even nightmares.
In a review of tests for the six most widely used antidepressants between 1987 and 1999--Prozac, Paxil, Zoloft, Celexa, Serzone
, and Effexor--Angell reported, "Most of them were negatives.
Psychologist Irving Kirsch and colleagues acquired FDA reviews of all placebo-controlled clinical studies (positive and negative) that led to the approval of Prozac, Paxil, Zoloft, Celexa, Serzone
, and Effexor.
In 2003, Health Canada (2003, November 10) also withdrew from the market the previously approved antidepressant nefazodone (Serzone
) due to liver-related adverse effects, making it the fifth approved antidepressant to be withdrawn for safety reasons since 1963 (Lexchin, 2005).
Newer antidepressants, nefazodone (Serzone
) and venlafaxine (Effexor), are recommended for patients who cannot tolerate or are not helped by an SSRI.
The authors looked at data on all of the studies submitted to the Food and Drug Administration for the licensing of the six most widely prescribed antidepressants that were approved between 1987 and 1999: fluoxetine, Effexor (venlafaxine), Serzone
(nefazodone), and Paxil.
Those trials compared randomly assigned placebo treatment to treatment with any one of four antidepressants--fluoxetine (Prozac), venlafaxine (Effexor), nefazodone (Serzone
), and paroxetine (Paxil).
These 8 studies evaluated clomipramine, fluoxetine, paroxetine, sertraline, citalopram (Celexa), fluvoxamine (Luvox), mirtazapine (Remeron), and nefazodone (Serzone
) against placebo.
Researchers found little difference in mildly depressed patients who took the antidepressants Prozac, Effexor, Serzone
and Seroxat/Paxil and those who took a dummy pill, or placebo.
Tanton identifies some 374 different mental conditions that were given definition to justify the use of Prozac, Paxil, Zoloft, Celexa, Wellbutrin, Zyban, Remeron, Serzone
, Effexor, Buspar, Risperdal, Zyprexa, Seroquel, Geodon, Depakote, and Adderall.
In The Blue of Her Body, Greenslit describes a character turned inside out by drugs that cycle through her without helping her--Effexor, Serzone
, Paxil, Zoloft, Prozac.