26) One branded version of nefazodone, Serzone
, was associated with rare but severe liver problems and was withdrawn from the U.
The other medication in this class, Serzone
(nefazodone), increases REM with subjective reports of vivid dreams or even nightmares.
Examples of drugs that have been withdrawn due to DILI include Oraflex, Duract, Marsilid, Serzone
, Diflurex, and Rezulin.
In a review of tests for the six most widely used antidepressants between 1987 and 1999--Prozac, Paxil, Zoloft, Celexa, Serzone
, and Effexor--Angell reported, "Most of them were negatives.
Psychologist Irving Kirsch and colleagues acquired FDA reviews of all placebo-controlled clinical studies (positive and negative) that led to the approval of Prozac, Paxil, Zoloft, Celexa, Serzone
, and Effexor.
The authors looked at data on all of the studies submitted to the Food and Drug Administration for the licensing of the six most widely prescribed antidepressants that were approved between 1987 and 1999: fluoxetine, Effexor (venlafaxine), Serzone
(nefazodone), and Paxil.
Researchers found little difference in mildly depressed patients who took the antidepressants Prozac, Effexor, Serzone
and Seroxat/Paxil and those who took a dummy pill, or placebo.
TABLE 2 FDA Approvals of New Psychotropic Drugs SSRIs Prozac (fluoxetine) December 1987 Zoloft (sertraline) December 1991 Paxil (paroxetine) December 1992 Luvox (fluvoxamine) December 1994 Celexa (citalopram) July 1998 Other antidepressants Effexor (venlafaxine) December 1993 Serzone
(nefazodone) December 1994 Wellbutrin (bupropion) December 1985 Remeron (mirtazapine) June 1996 Atypical antipsychotics Clozaril (clozapine) September 1986 Risperdal (risperidone) December 1993 Zyprexa (olanzapine) September 1996 Seroquel (quetiapine) September 1997 Geodon (ziprasidone) February 2001 TABLE 3 Overall and Medicaid-Only Expenditures on Antidepressants and Antipsychotics ($ Millions) 1997 2001 (A) Overall 1997 Share (%) 2001 Share (%) AAGR 97-01 (%) Antipsychotics Atypicals 1,434 84.
Tanton identifies some 374 different mental conditions that were given definition to justify the use of Prozac, Paxil, Zoloft, Celexa, Wellbutrin, Zyban, Remeron, Serzone
, Effexor, Buspar, Risperdal, Zyprexa, Seroquel, Geodon, Depakote, and Adderall.
In The Blue of Her Body, Greenslit describes a character turned inside out by drugs that cycle through her without helping her--Effexor, Serzone
, Paxil, Zoloft, Prozac.
xx Aventyl, Budeprion SR, bupropion, Celexa, clomipramine, desipramine, Desyrel, Effexor, Effexor XR, Elavil, Emitrip, fluoxetine, fluvoxamine maleate, imipramine, Lexapro, Ludiomil, Luvox, maprotiline, mirtazapine, nefazodone, Norpramin, nortriptyline, Pamelor, paroxetine, Paxil, Paxil CR, Pexeva, Prozac, Prozac Weekly, Remeron, Serzone
, Surmontil, Tofranil, Tofranil-PM, Trazodone, Vivactil, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zoloft Diabetes 250.
Quinine and Quinidine, Seroquel and Serzone
look very similar next to each other on the shelf, and are the most likely candidates for a mispick," he explains.