silent mutation

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Related to Silent mutations: Nonsense mutations, Missense mutations

silent mutation

n.
A genetic mutation that does not result in a change of phenotype.
Translations
mutation inapparente
References in periodicals archive ?
EX7_ 111G/C, EX7_113G/A, EX7_117C/A, EX7_118T/A, EX7_ 119T/C, EX7_120G/A, and EX7_121delC were silent mutations. The frequencies of alleles G and H were 0.59 and 0.41, respectively, and the analyzed population was in Hardy-Weinberg equilibrium (p>0.05).
In each case all variants listed in the most recent version of the NCBI (National Center for Biotechnology Information) dbSNP database were excluded as well as silent mutations. Low frequency frameshift and truncating mutations in any LGMD gene were considered pathogenic.
We believe that the role of such silent mutations in BrS will be much clearer as the number of the cases increase.
The novel dtxR sequences contained silent mutations and the novel frame-shift, missense, and/or nonsense mutations of the novel tox sequences.
To date, 142 mutations have been identified in the MEFV gene, most of which are substitutions (78 of them are missense, one nonsense, 39 silent mutations, 17 are located in introns, two in UTS), one is duplication, two are insertions and two are deletions.
Certain silent mutations and several novel mutations outside the hot-spot" region were also found.
Some SNPs have a direct or even pathogenic impact on coding sequences, but many do not--either because they are outside of coding regions, or because they are silent mutations (ones that do not change amino-acid sequence) when in coding regions.
DNA sequencing of direct patient samples (or if not available, isolates) with possible RMP resistance should include genetic loci associated with resistance to RMP (to include rpoB) as well as isoniazid (to include inhA and katG) to assess for multidrug/ resistant tuberculosis; rpoB mutations detected by the Xpert MTB/RIF assay might be silent mutations that do not affect RMP susceptibility.
To compare results generated from gDNA and WGA samples, we analyzed all detected variants, including SNPs, silent mutations, and variants located in introns or untranslated regions.
Three silent mutations in other sheep breeds, except for Minxian Black-fur and Kazakh Fat-Rumped breeds, have three genotypes.
Earlier it was reported that though it is silent mutations the heterozygous EGFR mutation (G/A genotype) group showed higher sensitivity (lower IC50 values) to gefitinib than the EGFR wt (G/G genotype) group did (Hsieh et al., 2006).