silymarin

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silymarin

(səˈlaɪmərɪn)
n
(Elements & Compounds) an antioxidant flavonoid found in milk thistle
[C20: from the genus name Silybum]
Translations

silymarin

n silimarina
References in periodicals archive ?
In animal research, silibinin was found to exert cancer-fighting effects against an advanced form of human prostate tumor cells, resulting in decreased proliferation and increased cancer-cell apoptosis.
Now a loud toot of the trumpet for silibinin, derived from an extract of milk thistle, a plant traditionally used to treat liver conditions.
Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition.
Up-Regulated Agents that Gene Down-regulate Gene Product Supplements Prescription Medications COX-2 EGCG (33), (34) Celebrex[R] (33), (44) curcumin (35-37) fish Indocin (44), (45) oil (38), (39) rosemary diclofenac (45) compounds (48), (49) FAS EGCG (46) GLA (47) Alli[R] (Xenical[R]) Vitamin D (48), (49) (50-52) HSP-2 Quercetin (53) DHA Celebrex[R] (54) (54) Ritonavir[R] (55) 17-AAG (56) VEGF-R methlselenol (57) Avastin[R] (62) curcumin (58) silibinin Tetracycline (63) ADT (59) indole-3-carbinol (64), (65) (60) EGCG (61) aminobisphosphonates (66) TABLE 3: Applying the Patient's Tumor Biology to Individualize Treatment.
Methods and results: According to the molecular docking screening, we reported here silibinin as a novel CXCR4 antagonist.
Herein, for the first time, we investigated the effect and associated mechanisms of silibinin phosphatidylcholine (silybin-phytosome) on established prostate tumors in transgenic adenocarcinoma of the mouse prostate (TRAMP) model.
Silibinin, a plant flavanoid from milk thistle, was shown to protect rat cardiac myocytes against injury through restoring the mitochondrial function and regulating the expression of Bcl-2 family members, as well as by inhibiting the release of pro-apoptotic cytochrome c from mitochondria (Zhou et al.
Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.
004 Female C57BL/6 mice (11 weeks of age, 20-25 g) were ovariectomized and orally supplemented with 10 mg/kg MTE and silibinin daily for 8 weeks.
58,60 Iron-overloaded animals can be protected from the liver fibrosis-inducing effects of iron by regular doses of silibinin, a milk thistle component.
Atorvastatin, Simvastatin, Berberine and Silibinin, that possess hypo-lipidemic and hepato-protective activities, have also been shown to inhibit lipid accumulation in adipocytes (Huang et al.
Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.