SV40

(redirected from Simian virus 40)
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Related to Simian virus 40: adenovirus

SV40

 (ĕs′vē-fôr′tē)
n.
A polyomavirus found in humans and other mammals that causes tumors in certain species, such as hamsters and rats, and various diseases in immunocompromised monkeys. It has been widely researched as a model of viral replication and gene expression and a possible cause of certain cancers in humans.

[s(imian) v(irus) 40.]
References in periodicals archive ?
Simian virus 40 detection in human mesothelioma: reliability and significance of the available molecular evidence.
Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblasts.
BK virus, JC virus, and simian virus 40 infection in humans, and association with human tumors.
After antigen retrieval with ethylenediaminetetraacetic acid at pH 8 and microwaving at 900 W (2 steps of 3 minutes, followed by 2 steps of 4 minutes), immunoperoxidase staining was performed using a polyclonal antibody against the VP1 through VP3 proteins of simian virus 40 (dilution, 1:20000; Lee Biomolecular Research Labs, San Diego, Calif), which cross-reacts with human BKV and JCV.
A virologist colleague had shown Twarock a 1991 scientific article that reported that every one of the 72 capsomers of a polyoma-type virus called Simian Virus 40 (SV-40) is a pentamer.
The UROtsa cell line was derived from the normal urothelium lining the ureter and was immortalized using the simian virus 40 (SV40) large T antigen (17,18).
Serologic studies have shown that most adults have been exposed to HPyVs, and cross-reactivity studies have shown antigenic similarities between simian virus 40 and BK polyomavirus and, to a lesser extent, between simian virus 40 and JC polyomavirus (3-5).
The latter genus consists of the BK virus, JC virus, and simian virus 40.
Liddington and his colleagues used synchrotron radiation to probe the crystal structure of simian virus 40, a cousin of the papillomavirus that causes warts in humans.
In every construct, the tag sequence included codes for the 11-aa KPPTPPPEPET epitope of simian virus 40 (SV40) large T-antigen (31,32).