Intec Pharma announces top-line data from the company's pivotal Phase 3 ACCORDANCE trial evaluating the safety and efficacy of the Accordion Pill-Carbidopa/Levodopa, or AP-CD/LD, compared with immediate release IR-CD/LD, or Sinemet
, as a treatment for the symptoms of advanced Parkinson's disease.
The PD drug levodopa (Sinemet
, Duopa) may be given to treat movement symptoms if they are severe.
A double-blind controlled study found that single dose of levodopa/carbidopa (Sinemet
CR) could not significantly improve total sleep time, sleep latency, and sleep fragmentation of PD patients (quality score, 62.5%).
His medical history also includes Parkinson disease treated with levodopa-carbidopa (Sinemet
), hypothyroidism, and peripheral neuropathy.
These medicines Stalevo 100MG/25MG/200MG and Sinemet
Plus tablets are quite effective and provide him with much relief.
Some medications (Sinemet
for Parkinson's disease, hydralazine for high blood pressure and isoniazid for tuberculosis, for example) can lead to B6 deficiencies, as can alcoholism, diabetes, asthma and lymphoma.
McDowell, "A double-blind crossover comparison of Sinemet
CR4 and standard Sinemet
25/100 in patients with Parkinson's disease and fluctuating motor performance," Journal of Neurology, Neurosurgery and Psychiatry, vol.
Neurology suspected that dysphagia was due to Parkinson's disease and recommended starting Sinemet
in the near future.
His bradykinesia, rigidity, intention tremor and postural hypotension continued to progress despite escalating doses of Sinemet
(Carbidopalevodopa), Mirapex (Pramipexole), and Symmetrel (Amantadine).
The most common drugs in this category used for sleep, specifically movement disorders, include Sinemet
(levodopa/carbidopa), dopamine agonists such as Requip (ropinirole), and Mirapex (pramipexole) both FDA approved for restless legs in recent years.
Relatively low risk: Parkinson's disease medications such as levodopa/carbidopa (Parcopa, Sinemet
) and amantadine; antihypertensive drugs such as Clonidine hydrochloride (Catapres); calcium channel blockers, such as diltiazem (including Cardizem and Dilacor), and verapamil (Calan); beta-blockers, such as atenolol (Tenormin), propanolol (Inderal) and timolol (Timoptic); the Alzheimer's disease drug donepezil (Aricept); hormone replacement drugs, such as estrogen (Enjuvia, Cenextin, etc.), medroxyprogesterone (Provera) and conjugated estrogens/medroxyprogesterone (Prempro); and benzodiazepines, such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and estazolam (ProSom).
Commonly used medications include: * Levodopa, examples: Sinemet
, Stalevo, Madopar.