Sir James Paget


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Noun1.Sir James Paget - English pathologist who discovered the cause of trichinosis (1814-1899)Sir James Paget - English pathologist who discovered the cause of trichinosis (1814-1899)
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"[Being a doctor] offers the most complete and constant union of those three qualities which have the greatest charm for pure and active minds 6 novelty, utility, and charity." aCo Sir James Paget
Osteitis deformans (Paget's disease of the bone) was first described as a chronic inflammation of the bone by Sir James Paget in 1877.[sup][1] Literature regarding its etiology primarily associates the disease to viral antigens, chromosomal translocations, and environmental factors but lacks substantial evidence.[sup][1],[2] Pathogenesis of the disease is characterized by accelerated osteoclastic activity followed by ineffective and chaotic osteoblastic activity resulting in a poorly mineralized and deformed bone that is highly vascular.[sup][3] Presentation of the disease is frequently polyostotic and rarely monostotic.
[1,7] In the mid 19th century, Sir James Paget first described a group at St.